Molecular Characterization of Alcohol-Ether Extract From Bovine Tissue

Kubelková, Klára; Hubálek, Martin; Řehulka, Pavel; Řehulková, Helena; Friedecký, David; Zakova, Jitka; Macela, Aleš

doi:10.31482/mmsl.2021.012

Cited by 3 publications

(7 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The contents of methionine and cysteine in Juvenil seem to be understated, however, because both are partially decomposed during hydrolysis. An analysis carried out at the Medical Faculty of Palacky University, Olomouc, Czech Republic, revealed a presence of taurine, which is an amino acid derivative of cysteine (24).…”

Section: What Does Juvenil Actually Contain?mentioning

confidence: 99%

“…Not identifiable, however, were peptide sequences corresponding to bovine VV-or LVV-hemorphins and spinorphin or a bovine heptapeptide (LVVYPWT) belonging to the hemorphin family. Among the peptides corresponding sequentially to other biologically active peptides were also identified sequences corresponding to β defensin 13, β-defensin 2, β-defensin 4, β-defensin 4 precursor, and β-defensin 5 (24).…”

Section: What Does Juvenil Actually Contain?mentioning

confidence: 99%

“…Juvenil also contains small amounts of dinucleotides, of which cytidine diphosphate has a significant presence. Even repeated analyses could not identify thymidine monophosphate, which is utilized as a monomer in DNA (24). For this reason, it is possible to assume that the content of nucleotides in Juvenil does not come from nuclear DNA but that it represents the content of free nucleotides in bovine blood plasma.…”

Section: Bostik Et Al: Juvenil and Modulation Of Gut Microbiota Compo...mentioning

confidence: 99%

“…Juvenil´s content of this component, however, appears to be entirely minor. The quantity of (phospho)lipids in Juvenil suggests that their content constitutes only a residuum of phospholipids that failed to be removed by the technology used in Juvenil's production (24).…”

Section: Bostik Et Al: Juvenil and Modulation Of Gut Microbiota Compo...mentioning

confidence: 99%

See 3 more Smart Citations

Juvenil, a Natural Immune Booster Affecting Biological Responses Through Modulation Of gut Microbiota Composition

Bostik,

Kubelková,

Macela

2024

MMSL

Self Cite

View full text Add to dashboard Cite

Juvenil, a nontoxic extract of bovine blood, is registered as a dietary supplement having no side effects. It contains a broad spectrum of free amino acids, as well as small proteins and oligopeptides (molecular weights up to 10 kDa), various nucleotides, and small amounts of phospholipids. The complex of these exclusively natural components has been shown to support physiological responses of supplemented organisms.Juvenil has been studied for several decades using a wide range of both experimental and clinical studies.Analyses have shown that it acts directly neither on individual functional systems of the body nor on individual metabolic processes. Current findings indicate that modulatory effects of Juvenil occur through modulation of gut microbiota composition, which is associated with the modulation of microbiota-gut-brain axis signaling. In murine model that modulatory effect is reflected in the expression of an early activation c-Fos marker in specific parts of the brain.In this review we present a set of findings about Juvenil, which has a wide range of positive effects on the functional systems of organisms. These effects can be used to strenghten the resistance, immunity, and regeneration of human beings. According to its effects Juvenil can be classified as a psychobiotics.

show abstract

Section: What Does Juvenil Actually Contain?mentioning

confidence: 99%

Section: What Does Juvenil Actually Contain?mentioning

confidence: 99%

Section: Bostik Et Al: Juvenil and Modulation Of Gut Microbiota Compo...mentioning

confidence: 99%

Section: Bostik Et Al: Juvenil and Modulation Of Gut Microbiota Compo...mentioning

confidence: 99%

See 2 more Smart Citations

Juvenil, a Natural Immune Booster Affecting Biological Responses Through Modulation Of gut Microbiota Composition

Bostik,

Kubelková,

Macela

2024

MMSL

Self Cite

View full text Add to dashboard Cite

show abstract

“…The lifestyle of patients, such as obesity, smoking, alcohol drinking, and beverage consumption could affect the disease profile and pathogenicity [51][52][53][54]. Types of drugs used for the treatment of COVID-19…”

Section: Polypharmacy and Lifestyle: Role Of Ageingmentioning

confidence: 99%

The Correlation between Age and Coronavirus Infections

Al-Tai¹,

Al-Hamdany²

2022

IJRMST

View full text Add to dashboard Cite

The global outbreak of coronavirus (COVID-19) in 2019 has attracted worldwide attention and increased concerns due to the rapid spread and progression of the disease. Despite the higher risk of death which is linked with COVID-19 in elderly patients, few studies have focused on how the clinical features and prognosis of COVID-19 patients differ between different age groups including 50 years, 50 to 60 years, and people aged above 60. A thorough assessment of age allows physicians to risk-stratify all COVID-19 patients regardless of where they are, as studies have shown that the clinical presentation and prognosis of the disease differ between age groups. Patients over 60 years of age have worse disease severity, more severe clinical symptoms and longer disease duration compared to those under 60 years of age. One of the major challenges facing public health and clinical experts during a pandemic is the diversity of disease severity. Understanding morbidity and mortality by age associated with COVID-19 is critical, as it affects treatment choices, prognostic expectations, and triage. This analysis concluded that patient clinical characteristics and disease prognosis change with age and that careful age assessment can help clinicians worldwide to risk-stratify all COVID-19 patients. In the present review, we do focus on the relationship between ageing and diseases profile or associated morbidities.

show abstract

Modulation of Gut Microbiome and Autism Symptoms of ASD Children Supplemented with Biological Response Modifier: A Randomized, Double-Blinded, Placebo-Controlled Pilot Study

Hrnciarova,

Kubelkova,

Bostik

et al. 2024

Nutrients

Self Cite

View full text Add to dashboard Cite

The etiology and mechanisms of autism and autism spectrum disorder (ASD) are not yet fully understood. There is currently no treatment for ASD for providing significant improvement in core symptoms. Recent studies suggest, however, that ASD is associated with gut dysbiosis, indicating that modulation of gut microbiota in children with ASD may thus reduce the manifestation of ASD symptoms. The aim of this pilot study (prospective randomized, double-blinded, placebo-controlled) was to evaluate efficacy of the biological response modifier Juvenil in modulating the microbiome of children with ASD and, in particular, whether Juvenil is able to alleviate the symptoms of ASD. In total, 20 children with ASD and 12 neurotypical children were included in our study. Supplementation of ASD children lasted for three months. To confirm Juvenil’s impact on the gut microbiome, stool samples were collected from all children and the microbiome’s composition was analyzed. This pilot study demonstrated that the gut microbiome of ASD children differed significantly from that of healthy controls and was converted by Juvenil supplementation toward a more neurotypical microbiome that positively modulated children’s autism symptoms.

show abstract

Molecular Characterization of Alcohol-Ether Extract From Bovine Tissue

Cited by 3 publications

References 36 publications

Juvenil, a Natural Immune Booster Affecting Biological Responses Through Modulation Of gut Microbiota Composition

Juvenil, a Natural Immune Booster Affecting Biological Responses Through Modulation Of gut Microbiota Composition

The Correlation between Age and Coronavirus Infections

Modulation of Gut Microbiome and Autism Symptoms of ASD Children Supplemented with Biological Response Modifier: A Randomized, Double-Blinded, Placebo-Controlled Pilot Study

Contact Info

Product

Resources

About