Molecular characterization of an avian GA13-like infectious bronchitis virus full-length genome from Costa Rica

Villalobos-Agüero, Ricardo A.; Ramírez-Carvajal, Lisbeth; Zamora-Sanabria, Rebeca; León, Bernal; Karkashian-Córdoba, James

doi:10.1007/s13337-021-00667-6

Cited by 5 publications

(4 citation statements)

References 32 publications

(39 reference statements)

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“…Our results revealed that IBV/Ck/Can/2558004 had 27, 710 nt long, consisting of 13 ORFs organized as 5′UTR-1a-1b-S-3a-3b-3c(E)-M-4b-4c-5a-5b-N-6b-3′UTR, and this agreed with previously characterized IBV isolates in some parts of the world [ 74 , 75 ]. Additionally, our findings showed the presence of a non-coding region consisting of eight nt located between genes N and 6b, which has been previously recognized [ 76 ].…”

Section: Discussionsupporting

confidence: 75%

Genotyping and In Silico Analysis of Delmarva (DMV/1639) Infectious Bronchitis Virus (IBV) Spike 1 (S1) Glycoprotein

Ali

Ojkić

Elshafiee

et al. 2022

Genes

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Genetic diversity and evolution of infectious bronchitis virus (IBV) are mainly impacted by mutations in the spike 1 (S1) gene. This study focused on whole genome sequencing of an IBV isolate (IBV/Ck/Can/2558004), which represents strains highly prevalent in Canadian commercial poultry, especially concerning features related to its S1 gene and protein sequences. Based on the phylogeny of the S1 gene, IBV/Ck/Can/2558004 belongs to the GI-17 lineage. According to S1 gene and protein pairwise alignment, IBV/Ck/Can/2558004 had 99.44–99.63% and 98.88–99.25% nucleotide (nt) and deduced amino acid (aa) identities, respectively, with five Canadian Delmarva (DMV/1639) IBVs isolated in 2019, and it also shared 96.63–97.69% and 94.78–97.20% nt and aa similarities with US DMV/1639 IBVs isolated in 2011 and 2019, respectively. Further homology analysis of aa sequences showed the existence of some aa substitutions in the hypervariable regions (HVRs) of the S1 protein of IBV/Ck/Can/2558004 compared to US DMV/1639 isolates; most of these variant aa residues have been subjected to positive selection pressure. Predictive analysis of potential N-glycosylation and phosphorylation motifs showed either loss or acquisition in the S1 glycoprotein of IBV/Ck/Can/2558004 compared to S1 of US DMV/1639 IBV. Furthermore, bioinformatic analysis showed some of the aa changes within the S1 protein of IBV/Ck/Can/2558004 have been predicted to impact the function and structure of the S1 protein, potentially leading to a lower binding affinity of the S1 protein to its relevant ligand (sialic acid). In conclusion, these findings revealed that the DMV/1639 IBV isolates are under continuous evolution among Canadian poultry.

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Section: Discussionsupporting

confidence: 75%

Genotyping and In Silico Analysis of Delmarva (DMV/1639) Infectious Bronchitis Virus (IBV) Spike 1 (S1) Glycoprotein

Ali

Ojkić

Elshafiee

et al. 2022

Genes

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“…The entire genome sequence has a sequence identity with that of the strain from Georgia, USA, of 94.03%, and the least similar sequence identity with that of the strain from China is 86.03%. The Costa Rican isolate, which shows 96.89% similarity with the S1 subunit of the Georgian strain, was identified as belonging to genotype I and lineage 17 (GI-17) ( Villalobos-Agüero et al., 2021 ).…”

Section: Genotypic Prevalence On Continentsmentioning

confidence: 99%

Avian infectious bronchitis virus (AIBV) review by continent

Rafique,

Jabeen,

Pervaiz

et al. 2024

Front. Cell. Infect. Microbiol.

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Infectious bronchitis virus (IBV) is a positive-sense, single-stranded, enveloped RNA virus responsible for substantial economic losses to the poultry industry worldwide by causing a highly contagious respiratory disease. The virus can spread quickly through contact, contaminated equipment, aerosols, and personal-to-person contact. We highlight the prevalence and geographic distribution of all nine genotypes, as well as the relevant symptoms and economic impact, by extensively analyzing the current literature. Moreover, phylogenetic analysis was performed using Molecular Evolutionary Genetics Analysis (MEGA-6), which provided insights into the global molecular diversity and evolution of IBV strains. This review highlights that IBV genotype I (GI) is prevalent worldwide because sporadic cases have been found on many continents. Conversely, GII was identified as a European strain that subsequently dispersed throughout Europe and South America. GIII and GV are predominant in Australia, with very few reports from Asia. GIV, GVIII, and GIX originate from North America. GIV was found to circulate in Asia, and GVII was identified in Europe and China. Geographically, the GVI-1 lineage is thought to be restricted to Asia. This review highlights that IBV still often arises in commercial chicken flocks despite immunization and biosecurity measures because of the ongoing introduction of novel IBV variants and inadequate cross-protection provided by the presently available vaccines. Consequently, IB consistently jeopardizes the ability of the poultry industry to grow and prosper. Identifying these domains will aid in discerning the pathogenicity and prevalence of IBV genotypes, potentially enhancing disease prevention and management tactics.

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“…For example, in North America, various indigenous genotypes have been identified, including GI-8, GI-9, GI-17, GI-20, GI-25, GI-27, GIV-1, GVIII-1, with GI-20 reported exclusively in Canada [74]. Interestingly, GI-17 has been isolated recently from outbreaks during 2016-2017 in Costa Rica [122]. Mexico is endemic with GI-31 and GIX [123] (discussed later in this review).…”

Section: Emergence and Dissemination Of Ibv Variants Worldwidementioning

confidence: 99%

Global Emergence of Infectious Bronchitis Virus Variants: Evolution, Immunity, and Vaccination Challenges

Abozeid

2023

Transboundary and Emerging Diseases

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Infectious bronchitis is an acute, extremely contagious viral disease affecting chickens of all ages, leading to devastating economic losses in the poultry industry worldwide. Affected chickens show respiratory distress and/or nephritis, in addition to decrease of egg production and quality in layers. The avian coronavirus, infectious bronchitis virus (IBV), is a rapidly evolving virus due to the high frequency of mutations and recombination events that are common in coronaviruses. This leads to the continual emergence of novel genotypes that show variable or poor crossprotection. The immune response against IBV is complex. Passive, innate and adaptive humoral and cellular immunity play distinct roles in protection against IBV. Despite intensive vaccination using the currently available live-attenuated and inactivated IBV vaccines, IBV continues to circulate, evolve, and trigger outbreaks worldwide, indicating the urgent need to update the current vaccines to control the emerging variants. Different approaches for preparation of IBV vaccines, including DNA, subunit, peptides, virus-like particles, vectored and recombinant vaccines, have been tested in many studies to combat the disease. This review focuses on several key aspects related to IBV, including its clinical significance, the functional structure of the virus, the factors that contribute to its evolution and diversity, the types of immune responses against IBV, and the characteristics of both current and emerging IBV vaccines. The goal is to provide a comprehensive understanding of IBV and explore the emergence of variants, their dissemination around the world, and the challenges to define the efficient vaccination strategies.

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Molecular characterization of an avian GA13-like infectious bronchitis virus full-length genome from Costa Rica

Cited by 5 publications

References 32 publications

Genotyping and In Silico Analysis of Delmarva (DMV/1639) Infectious Bronchitis Virus (IBV) Spike 1 (S1) Glycoprotein

Genotyping and In Silico Analysis of Delmarva (DMV/1639) Infectious Bronchitis Virus (IBV) Spike 1 (S1) Glycoprotein

Avian infectious bronchitis virus (AIBV) review by continent

Global Emergence of Infectious Bronchitis Virus Variants: Evolution, Immunity, and Vaccination Challenges

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