Molecular characterization of chicken anemia virus outbreaks in Nagpur province, India from 2012 to 2015

Ganar, Ketan; Shah, Manisha; Kamdi, Bhupesh; Kurkure, N. V.; Kumar, Sachin

doi:10.1016/j.micpath.2016.11.017

Cited by 15 publications

(6 citation statements)

References 56 publications

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“…After its first report in 1979, in Japan ( 34 ), CAV has been detected worldwide. The diversity of CAV strains in different countries has been reported previously ( 35 – 37 ). In recent years, CAV infections have been detected in Guangdong, Shandong, and Heilongjiang provinces of China ( 2 , 16 , 28 , 38 , 39 ).…”

Section: Discussionsupporting

confidence: 54%

Genomic Sequence and Pathogenicity of the Chicken Anemia Virus Isolated From Chicken in Yunnan Province, China

et al. 2022

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Chicken anemia virus (CAV), which has been reported in many countries, causes severe anemia and immunosuppression in chickens. In this study, a CAV strain YN04 belonging to genotype A was first identified from infected chickens in Yunnan province, China. Moreover, the animal infection experiments further confirmed that the strain YN04 is a highly pathogenic strain, which can cause 86.67% mortality in chickens in the infection group. The mean death time of infected chickens was 13.1 days post infection (dpi). CAV infection induced severe anemia with significant decrease in packed cell volume (PCV), and serious atrophy and lesion of thymus and bursa with high viral load at 14 dpi. Besides, CAV infection caused a sharp decrease in chicken body weight and immune organ indices including the ratio of thymus or bursa to body weight at 21 dpi, which displayed the potential immunosuppression state at this stage. These findings enrich the epidemiological data on CAV and may provide information for preventing its further spread in Yunnan province, China.

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Section: Discussionsupporting

confidence: 54%

Genomic Sequence and Pathogenicity of the Chicken Anemia Virus Isolated From Chicken in Yunnan Province, China

et al. 2022

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“…It was reported that the amino acid in the 394. position of VP1 protein has a major genetic determinant of virulence (Yamaguchi et al, 2001). Ganar et al (2017) determined glutamine aa. in the 394. position of VP1 protein of all 11 CAV field isolates obtained from India.…”

Section: Discussionmentioning

confidence: 99%

Full-Length Genomic Characterization of Chicken Anemia Virus in Turkey

Aşkar

2019

Braz. J. Poult. Sci.

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Chicken infectious anemia (CIA) is an immune-suppressive disease caused by chicken anemia virus (CAV). It is characterized by lymphoid atrophy, aplastic anemia, especially in chicks. In this study, full-length genomic characterization of CAV DNA from the broiler flocks in Turkey and phylogenetic analysis were aimed. In the study, CAV DNA were found positive for 37 (53%) flocks with PCR studies from thymus tissues of each 70 broiler flocks. And 17 purified CAV DNA PCR products from these 37 CAV isolates were full length sequenced with the NGS method (Illumina MiSeq). Also with the phylogenetic analyses, full length PCR products of 17 purified CAV isolates have been determined as 2298bp genome size and 99% similarity with each other. The highest similarity (99%) has been detected with the isolates from China and Taiwan. Furthermore, a 97-98% similarity has been detected with vaccine strains (Cux-1, 26P4 and Del Ros) and also 88-90 % similarity has been detected with GyV4 and GyV3 isolates. As a result, in the study full length genomic characterization of CAV DNA from the 7 regions of Turkey were determined. And also all Turkish CAV isolates and vaccine strains were in group 2 according to the phylogenetic tree were obtained. But these isolates and vaccine strains were not found in the same group with GyV3 and GyV4 strains. Besides, these CAV isolates were showed more similarity to the isolates reported from Taiwan and China than the vaccine strains.

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“…Both viral proteins 1 and 2 are prime targets in vaccine design to induce neutralizing antibodies in the host, mainly chickens (Moeini et al, 2011). Viral protein 3 is regarded as Apoptin, as it facilitates apoptosis in the transformed cells, making it a potential agent in the control of cancer disease (Ganar et al, 2017). CAV affects both male and female chickens of all ages, thereby contributing to the severe damage it causes in the poultry industry (Umar et al, 2014).…”

Section: Chicken Anemia Virus (Cav)mentioning

confidence: 99%

Chicken anemia virus: A deadly pathogen of poultry

Fatoba¹,

Adeleke²

2019

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Chicken infectious anemia (CIA) is an immunosuppressive disease that causes great economic loss in poultry industry globally. This disease is caused by chicken anemia virus (CAV), an icosahedral and single-stranded DNA virus that is transmitted both vertically and horizontally. CAV, which belongs to the genus Gyrovirus has been reported in human, mouse and dog feces. Rapid identification of different strains of gyrovirus with high similarity to CAV has heightened public concern on this virus. Clinical symptoms of this disease such as intramuscular hemorrhage, weight loss, anemia and bone marrow aplasia are prominent in young chickens, while adult chickens experience subclinical symptoms. Biosecurity measures such as good management practice and vaccination have been the most reliable control strategy against this virus. Therefore, this study reviews the current state of CAV under the following subheadings (i) Chicken anemia virus (ii) Pathogenesis of CAV (iii) Serological evaluation of host antibodies to CAV (iv) Association of Marek's disease and infectious bursa disease with CAV infection (v) Genetic diversity and phylogenetics of CAV strains (vi) Current and future vaccine strategy in the control of CAV. In conclusion, improvement on DNA and recombinant vaccines strategy could curtail the economic impact of CAV on poultry birds.

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Molecular characterization of chicken anemia virus outbreaks in Nagpur province, India from 2012 to 2015

Cited by 15 publications

References 56 publications

Genomic Sequence and Pathogenicity of the Chicken Anemia Virus Isolated From Chicken in Yunnan Province, China

Genomic Sequence and Pathogenicity of the Chicken Anemia Virus Isolated From Chicken in Yunnan Province, China

Full-Length Genomic Characterization of Chicken Anemia Virus in Turkey

Chicken anemia virus: A deadly pathogen of poultry

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