Molecular Characterization of Clear Cell Lesions of Head and Neck

Jain, Abhishek; Shetty, Devi Charan; Juneja, Saurabh; Narwal, Nidhi

doi:10.7860/jcdr/2016/14394.7867

Cited by 21 publications

(23 citation statements)

References 12 publications

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“…Therefore, in consideration of the reported typical reactivity of CCRCC, PAS, with and without diastase treatment, vimentin, CD 10, EMA, RCCAg, and PAX-8 should be included [15,[26][27][28][29]. In consideration of the results of the current study, we argue the practical usefulness of EMA and vimentin in this setting, due to consistent immunoreactivity for such markers in many distinct salivary gland tumors and, to a lesser extent, in odontogenic tumors as well.…”

Section: Discussionmentioning

confidence: 99%

“…HCCC, instead, is a tumor predominantly occurring in minor salivary glands, which is immunostochemically negative for S100, smooth muscle actin, calponin and glial fibrillary acidic protein (GFAP) but positive for pan-cytokeratins and p63. The latter marker may be of pivotal relevance in this regard, being consistently negative in renal cell carcinoma [2,11,13,26].…”

Section: Discussionmentioning

confidence: 99%

“…The presence of calcified deposits and amorphous eosinophilic material positive for Congo red and birefringent under polarized light surely facilitates the diagnosis of CEOT, the latter being also PAS-negative, at variance with CCRCC. CCOC is characterized by clusters of clear cell nests with ameloblastoma-like peripheral palizading; the tumor cells usually are PAS-positive but, at variance with CCRCC, they demonstrate S-100 protein and melanoma-associated antigen (MAA) immunoreactivity [2,12,13,26].…”

Section: Discussionmentioning

confidence: 99%

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Metastatic Tumors of the Oro-Facial Tissues: Clear Cell Renal Cell Carcinoma. A Clinico-Pathological and Immunohistochemical Study of Seven Cases

Capodiferro

Limongelli

Mastropasqua

et al. 2020

JCM

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Metastases to orofacial tissues are infrequent, their incidence being 1%–8% of malignant oral tumors, sometimes manifesting as the first clinical sign of an occult cancer. Renal cell carcinoma (RCC) is the second most common metastatic carcinoma to the oro-facial tissues, involving the jawbones, gingiva, oral mucosa, tongue or salivary glands. Also, RCC frequently displays a prominent clear cell component, which may predominate in the clear cell renal cell carcinoma subtype (CCRCC) and histologically mimic many other clear cell tumors, both benign and malignant, which can be epithelial (from keratinizing epithelia, cutaneous adnexa, salivary glands and odontogenic epithelium), melanocytic or mesenchymal in origin. In view of the necessity for prompt and accurate diagnosis of such unusual neoplasms, we report on the salient clinico-pathological features of 7 CCRCC metastatic to the oro-facial tissues, and highlight their immunohistochemical profile, to more accurately discriminate this neoplasm from other tumors of the oral cavity with a prominent clear cell component.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Metastatic Tumors of the Oro-Facial Tissues: Clear Cell Renal Cell Carcinoma. A Clinico-Pathological and Immunohistochemical Study of Seven Cases

Capodiferro

Limongelli

Mastropasqua

et al. 2020

JCM

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“…Mucoepidermoid carcinoma is manifested by the presence of intermediate, epidermoid and mucous cells along with clear cell component. [ 9 11 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 12 ] Eversole drew similarities between the normal enamel organ and then known CCOT to prove that CCOC could arise from odontogenic epithelium. [ 11 ] Clear cells in odontogenic tumors are believed to originate from dental lamina recapitulating a phase of amelogenesis in which they accumulate glycogen. Eversole advocated these clear cells to be related to presecretory ameloblast and epithelial in nature, containing desmosomes and lacking secretory granules.…”

Section: Discussionmentioning

confidence: 99%