2000
DOI: 10.1074/jbc.m003277200
|View full text |Cite
|
Sign up to set email alerts
|

Molecular Characterization of CRMP5, a Novel Member of the Collapsin Response Mediator Protein Family

Abstract: The CRMP (collapsin response mediator protein) family is thought to play key roles in growth cone guidance during neural development. The four members (CRMP1-4) identified to date have been demonstrated to form hetero-multimeric structures through mutual associations. In this study, we cloned a novel member of this family, which we call CRMP5, by the yeast twohybrid method. This protein shares relatively low amino acid identity with the other CRMP members (49 -50%) and also with dihydropyrimidinase (51%), wher… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

2
129
2
3

Year Published

2001
2001
2017
2017

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 119 publications
(136 citation statements)
references
References 46 publications
2
129
2
3
Order By: Relevance
“…Our demonstration, by double labeling, of the coexpression of these two Ulip/CRMPs in a subpopulation of oligodendrocytes corroborates previous reports of specific interactions between Ulip/CRMP isoforms (Wang and Strittmatter, 1997;Fukada et al, 2000;Inatome et al, 2000). Expression of Ulip1/CRMP4 protein has also been described in adult brain oligodendrocytes (Nacher et al, 2000).…”
Section: Molecular and Cellular Characterization Of Ulip6/crmp5supporting
confidence: 78%
See 2 more Smart Citations
“…Our demonstration, by double labeling, of the coexpression of these two Ulip/CRMPs in a subpopulation of oligodendrocytes corroborates previous reports of specific interactions between Ulip/CRMP isoforms (Wang and Strittmatter, 1997;Fukada et al, 2000;Inatome et al, 2000). Expression of Ulip1/CRMP4 protein has also been described in adult brain oligodendrocytes (Nacher et al, 2000).…”
Section: Molecular and Cellular Characterization Of Ulip6/crmp5supporting
confidence: 78%
“…During the course of this manuscript preparation, a fifth member with 50% homology with other Ulip/CRMPs was described in rat (CRAM) (Inatome et al, 2000) and mouse (CRMP5) (Fukada et al, 2000) brain. CRAM was discovered when antibodies against Zap-70, a Syk tyrosine kinase essential for T lymphocyte function, were found to cross-react with a protein kinase interacting with CRAM, and CRMP5 was discovered while studying molecules involved in regional specificity of the retina.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Furthermore, the FK-down genes are highly expressed in either proliferating cells in the EGLa or premigratory postmitotic cells in the EGLb, or both, whereas the FK-up genes are predominantly expressed in the postmigratory cells in the IGL. The identified FK-down genes include CAR (coxsackie-and adenovirus receptor) (37), CLMP (coxsackie-and adenovirus receptor-like membrane protein) (38), Tmeff1 (tomoregulin-1) (39), CRMP4 (Dpsyl3 or Ulip) (40), and CRMP5 (Dpsyl5) (41). These molecules have been implicated in cell adhesion and transmembrane and intracellular signalings.…”
Section: Discussionmentioning
confidence: 99%
“…CRMPs are now known to be composed of five homologous cytosolic proteins; all of the family proteins are phosphorylated and are highly expressed in developing and adult nervous systems (Wang and Strittmatter, 1996;Fukada et al, 2000;Inatome et al, 2000;Yuasa-Kawada et al, 2003). CRMPs also mediate other signaling, such as NT3, and are involved in many aspects of neuronal cell development by regulating cytoskeletal organization (Goshima et al, 1995Quach et al, 2004;Arimura and Kaibuchi, 2005;Uchida et al, 2005;Yoshimura et al, 2005).…”
Section: Introductionmentioning
confidence: 99%