Molecular Characterization of Desmoid Tumors: Decryption of the Enigma

Place, Trenton L.; Mezhir, James J.

doi:10.1159/000344005

Cited by 1 publication

(1 citation statement)

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“…Abdominal wall tumor location is associated with the best prognosis, while chest wall, intra-abdominal, and extremity locations are associated with worse prognostic outcomes [18]. Neither margin status nor radiotherapy was found to be statistically significant in affecting outcome [18]. …”

Section: Discussionmentioning

confidence: 99%

Desmoid Fibromatosis Presenting as Deep Venous Thrombosis: A Case Report and Discussion

Marks¹,

Neuhaus

2016

Am J Case Rep

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Patient: Male, 40Final Diagnosis: Desmoid fibromatosisSymptoms: DiscomfortMedication: —Clinical Procedure: Surgery and radiotherapySpecialty: SurgeryObjective:Rare diseaseBackground:Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common, serious cardiovascular event. Predisposing factors include genetic disorders, immobility, and underlying malignancy. Soft tissue tumors are by contrast rare, but should be included in the differential etiology of DVT, especially when the patient is young and has few thrombotic risk factors.Case Report:We present a 40-year-old patient whose initial diagnosis was spontaneous DVT of the lower leg, treated conventionally. Subsequently, he developed progressive calf swelling, which was diagnosed as multifocal desmoid fibromatosis, a rare and complex soft tissue tumor.Conclusions:DVT is common but soft tissue tumors are rare. The disparity in incidence of these very distinct pathologies may contribute to late diagnosis of occult soft tissue pathology. We discuss the incidence, etiology, pathology, diagnosis, and best management of both desmoid fibromatosis and DVT, which may co-exist in a causative way.

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Section: Discussionmentioning

confidence: 99%