Molecular characterization of Hsf1 as a master regulator of heat shock response in the thermotolerant methylotrophic yeast Ogataea parapolymorpha

Choo, Jin Ho; Lee, Su-Bin; Moon, Hye Yun; Lee, Kun Hwa; Yoo, Su Jin; Kim, Keun Pil; Kang, Hyun Ah

doi:10.1007/s12275-021-0646-2

Cited by 3 publications

(1 citation statement)

References 55 publications

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“…S. cerevisiae uses complex regulatory mechanisms to respond to temperature stress. One such mechanism involves the regulation of tryptophan metabolism ( Pan et al, 2019 ; Shen et al, 2020 ; Choo et al, 2021 ). S. cerevisiae commonly encounters high-temperature stress during the process of fermentation.…”

Section: L-trp Regulation Reform S Cerevisiae Stre...mentioning

confidence: 99%

A comprehensive review and comparison of L-tryptophan biosynthesis in Saccharomyces cerevisiae and Escherichia coli

Ren,

Wei,

Zhao

et al. 2023

Front. Bioeng. Biotechnol.

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L-tryptophan and its derivatives are widely used in the chemical, pharmaceutical, food, and feed industries. Microbial fermentation is the most commonly used method to produce L-tryptophan, which calls for an effective cell factory. The mechanism of L-tryptophan biosynthesis in Escherichia coli, the widely used producer of L-tryptophan, is well understood. Saccharomyces cerevisiae also plays a significant role in the industrial production of biochemicals. Because of its robustness and safety, S. cerevisiae is favored for producing pharmaceuticals and food-grade biochemicals. However, the biosynthesis of L-tryptophan in S. cerevisiae has been rarely summarized. The synthetic pathways and engineering strategies of L-tryptophan in E. coli and S. cerevisiae have been reviewed and compared in this review. Furthermore, the information presented in this review pertains to the existing understanding of how L-tryptophan affects S. cerevisiae’s stress fitness, which could aid in developing a novel plan to produce more resilient industrial yeast and E. coli cell factories.

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Section: L-trp Regulation Reform S Cerevisiae Stre...mentioning

confidence: 99%

A comprehensive review and comparison of L-tryptophan biosynthesis in Saccharomyces cerevisiae and Escherichia coli

Ren,

Wei,

Zhao

et al. 2023

Front. Bioeng. Biotechnol.

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Heat shock in Cronobacter sakazakii induces direct protection and cross-protection against simulated gastric fluid stress

et al. 2022

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A review of yeast: High cell-density culture, molecular mechanisms of stress response and tolerance during fermentation

Shen

Weng

et al. 2022

FEMS Yeast Research

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Yeast is widely used in fermentation industry, and the major challenges in fermentation production system are high capital cost and low reaction rate. High cell-density culture is an effective method to increase the volumetric productivity of the fermentation process, thus making the fermentation process faster and more robust. During fermentation, yeast is subjected to various environmental stresses, including osmotic, ethanol, oxidation and heat stress. To cope with these stresses, yeast cells need appropriate adaptive responses to prevent stress-induced cell damage and to acquire stress tolerances. A single stimulus can trigger multiple effects, and general as well as specific stress responses are required for comprehensive cell protection. Since all these stresses disrupt protein structure, the upregulation of heat shock proteins and trehalose is induced upon when yeast cells are exposed to stress. Understanding the research status of HCDC of yeast and its response mechanism to various stress conditions will help to improve fermentation efficiency, formulate effective fermentation control strategies, and improving stress resistance and fermentation performance of yeast.

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Molecular characterization of Hsf1 as a master regulator of heat shock response in the thermotolerant methylotrophic yeast Ogataea parapolymorpha

Cited by 3 publications

References 55 publications

A comprehensive review and comparison of L-tryptophan biosynthesis in Saccharomyces cerevisiae and Escherichia coli

A comprehensive review and comparison of L-tryptophan biosynthesis in Saccharomyces cerevisiae and Escherichia coli

Heat shock in Cronobacter sakazakii induces direct protection and cross-protection against simulated gastric fluid stress

A review of yeast: High cell-density culture, molecular mechanisms of stress response and tolerance during fermentation

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