Molecular characterization of long terminal repeat of porcine endogenous retroviruses in Chinese pigs

Zhang, P; Yu, Pengbo; Wang, W; Zhang, L; Li, S F; Bu, Hong

doi:10.4149/av_2010_03_165

Cited by 4 publications

(3 citation statements)

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“…The first type is characteristic of PERV-A and -B and contains repeated 39 bp sequences. Each repeat consists of one 18 bp and one 21 bp subrepeat sequence ( Krach et al, 2001 ; Scheef et al, 2001 ; Denner et al, 2003 ; Tonjes and Niebert, 2003 ; Zhang et al, 2010b ). Various types of subrepeat sequences have been observed ( Huh et al, 2007 ).…”

Section: Perv Molecular Structurementioning

confidence: 99%

Porcine Endogenous Retrovirus (PERV) – Molecular Structure and Replication Strategy in the Context of Retroviral Infection Risk of Human Cells

et al. 2018

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The xenotransplantation of porcine tissues may help overcome the shortage of human organs for transplantation. However, there are some concerns about recipient safety because the risk of porcine endogenous retrovirus (PERV) transmission to human cells remains unknown. Although, to date, no PERV infections have been noted in vivo, the possibility of such infections has been confirmed in vitro. Better understanding of the structure and replication cycle of PERVs is a prerequisite for determining the risk of infection and planning PERV-detection strategies. This review presents the current state of knowledge about the structure and replication cycle of PERVs in the context of retroviral infection risk.

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Section: Perv Molecular Structurementioning

confidence: 99%

Porcine Endogenous Retrovirus (PERV) – Molecular Structure and Replication Strategy in the Context of Retroviral Infection Risk of Human Cells

et al. 2018

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“…These discordances define another group of hosts for viruses that belong to different types. DNA analysis of PERV has shown that they pre serve all the structural features of retroviruses which are able to replicate (Akiyoshi et al, 1998;Czauderna et al, 2000;Tonjes et al, 2000;Krach et al, 2001;Park et al, 2010;Zhang et al, 2010a). The ability to repli cate differentiates these typical PERV from other fam ilies of gamma and beta retroviruses, which are defective upon replication and, thus, have no special significance for evaluation of the inherent risks when porcine tissues are transplanted (Ericsson et al, 2001;Patience et al, 2001).…”

Section: Molecular Genetic Characteristics Of Pervmentioning

confidence: 96%

Porcine endogenous retroviruses: What are the risks of infection transmission in xenotransplantation?

Yudin

Aitnazarov

Ermolaev

2011

Russ J Genet Appl Res

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Modern studies on porcine endogenous retroviruses are considered in the review. Data on the nucleotide sequences of retroviruses, their expression, and the isolation of mature virions is discussed. The tropism of endogenous retroviruses to human cells and retrospective studies of patients are considered in detail. A critical overview of works on in vitro and in vivo interspecific transmission of porcine endogenous retroviruses is presented. Tactics for preventing possible infection and treating humans for it are discussed. Based on the overviewed data, it is concluded that the risk of infection transmission from xenograft recipients to the rest of the population is very low. This low risk can be further reduced by careful observation and, prob ably, vaccination of contacting persons, as well as by preventive use of antiviral drugs. The minor risk of infec tion transmission can also be reduced by application of modern biotechnological methods to raise pigs that have no endogenous viruses tropic to humans.

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“…Finally, Zhang et al [18] characterized PERV LTR sequences from Banna inbred minipigs, Wu-Zhi-Shan pigs, and Neijiang pigs, and compared them with known PERV sequences (PERV-A, PERV-B, PERV-C, PERV-NIH, and 293-PERV-43). The LTR sequences of Banna minipigs and Wu-Zhi-Shan pigs were identical to those of PERV-A and PERV-B, while those of Neijiang pigs were more similar to PERV-C and PERV-NIH.…”

Section: Xenozoonosismentioning

confidence: 99%

Xenotransplantation literature update: November–December, 2010

Schneider

2011

Xenotransplantation

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Molecular characterization of long terminal repeat of porcine endogenous retroviruses in Chinese pigs

Cited by 4 publications

References 0 publications

Porcine Endogenous Retrovirus (PERV) – Molecular Structure and Replication Strategy in the Context of Retroviral Infection Risk of Human Cells

Porcine Endogenous Retrovirus (PERV) – Molecular Structure and Replication Strategy in the Context of Retroviral Infection Risk of Human Cells

Porcine endogenous retroviruses: What are the risks of infection transmission in xenotransplantation?

Xenotransplantation literature update: November–December, 2010

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