2017
DOI: 10.1016/j.meegid.2016.09.012
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Molecular characterization of multidrug-resistant Mycobacterium tuberculosis isolates from high prevalence tuberculosis states in Mexico

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Cited by 24 publications
(27 citation statements)
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“…Such variations in the occurrence of mutations associated with resistance 13 to E are similar to those reported previously [49]. Resistant isolates lacking in mutations 14 and the presence of mutations related to resistance in sensitive isolates show the possibility 15 of failures in the BACTEC MGIT phenotypic assay, and further analysis is required in 16 order to identify the factors that cause this low sensitivity and to improve the efficiency of 17 WGS in predicting resistance against this drug among the isolates from the setting.…”
supporting
confidence: 88%
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“…Such variations in the occurrence of mutations associated with resistance 13 to E are similar to those reported previously [49]. Resistant isolates lacking in mutations 14 and the presence of mutations related to resistance in sensitive isolates show the possibility 15 of failures in the BACTEC MGIT phenotypic assay, and further analysis is required in 16 order to identify the factors that cause this low sensitivity and to improve the efficiency of 17 WGS in predicting resistance against this drug among the isolates from the setting.…”
supporting
confidence: 88%
“…Moreover, increasing numbers of XDR-TB 12 cases are reported every year [22]. These figures make Mexico the country in the Americas 13 with the third highest contribution of tuberculosis, including aggravated forms of TB such 14 as DR-TB, MDR-TB and possibly XDR-TB. [23] Previous studies using Sanger 15 sequencing protocols have shown that Mexico presents a considerable diversity of 16 mutations associated with DR-TB, as well as variations related to geographical regions 17 [24][25][26][27][28][29][30][31], which act to limit the utility of new genotypic diagnostic procedures and make 18 WGS a very attractive alternative.…”
mentioning
confidence: 99%
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