Molecular characterization of Mycobacterium tuberculosis isolates from elephants of Nepal

Paudel, Sarad; Mikota, Susan K.; Nakajima, Chie; Gairhe, Kamal P.; Maharjan, Bhagwan; Thapa, Jeewan; Poudel, Ajay; Shimozuru, Michito; Suzuki, Yasuhiko; Tsubota, Toshio

doi:10.1016/j.tube.2013.12.008

Cited by 23 publications

(25 citation statements)

References 26 publications

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“…However, the antigens used are common for the MTBCs so they cannot differentiate MTBC subspecies including M. orygis. Also, the M. tuberculosis strain isolated from three of the cases in Nepal was identified as the same strain found in Nepalese human TB patients [22].…”

Section: Elephant Tb In South Asiamentioning

confidence: 61%

“…Complementing this finding, from our studies in Bangladesh [21], we have demonstrated a wide distribution of M. orygis in the region. Recent studies also point to an emerging challenge caused by TB to elephants, as Asian elephants in Nepal have been shown to be infected with M. tuberculosis [22], elephants in India were seroreactive to TB antigens [23], and TB was detected from a wild elephant in Sri Lanka [24]. Additionally, we will discuss some case reports that describe TB in other wildlife.…”

Section: Introductionmentioning

confidence: 99%

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Wildlife Tuberculosis: An Emerging Threat for Conservation in South Asia

Thapa¹,

Nakajima²,

Gairhe³

et al. 2017

Global Exposition of Wildlife Management

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Wildlife tuberculosis (TB) is becoming one of the emerging challenges for conservation globally. South Asian region is home to many endangered species like Asian elephants, rhinoceros, and Bengal tigers. Although it carries more than one-third of global burden of human TB, TB in livestock and wildlife has not been adequately studied. This chapter reviews the present knowledge and information about animal-adapted members of Mycobacterium tuberculosis complex and wildlife TB in South Asia. Recent studies of TB from different wild animals in Nepal and Bangladesh have found that M.orygis is an emerging threat of wildlife TB in the region. These studies have demonstrated wide diversity of M. orygis strains circulating in the region indicating its endemic distribution. M. orygis-associated TB was discovered from a free-ranging rhinoceros in Nepal and the finding could signify threat of TB in other wild animals, including a possibility of unknown maintenance host. Recent studies also revealed an emerging challenge caused by TB to elephants in different South Asian countries like Nepal, India, and Sri Lanka.Wildlife TB is becoming a conservation challenge in South Asia, but given the paucity of research in this area, it is overlooked and underexplored.

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Section: Elephant Tb In South Asiamentioning

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Wildlife Tuberculosis: An Emerging Threat for Conservation in South Asia

Thapa¹,

Nakajima²,

Gairhe³

et al. 2017

Global Exposition of Wildlife Management

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“…Through this work, I isolated Mycobacterium tuberculosis from three elephants that had died of suspected TB. Molecular characterisation revealed that the M tuberculosis isolates belonged to the Indo-oceanic lineage that is also found in the TB-infected human population in Nepal (Paudel and others 2014). My work demonstrated the transmission of TB at the elephant-human interface.…”

Section: Elephant Tb Researchmentioning

confidence: 99%

My life with elephants

Paudel¹

2017

Veterinary Record

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“…Culture of trunk wash samples is regarded as the standard method for the diagnosis of TB in elephants; however, this method has many limitations ( 2 ). We previously reported TB in 3 elephants in Nepal that was caused by M. tuberculosis of Indo-Oceanic lineage ( 3 ). Here, we report on mixed M. tuberculosis lineage infection in 2 captive elephants from Chitwan National Park (CNP) in Nepal.…”

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confidence: 99%

MixedMycobacterium tuberculosisLineage Infection in 2 Elephants, Nepal

Paudel¹,

Nakajima²,

Mikota³

et al. 2019

Emerg. Infect. Dis.

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Tuberculosis in elephants is primarily caused by Mycobacterium tuberculosis . We identified mixed M. tuberculosis lineage infection in 2 captive elephants in Nepal by using spoligotyping and large sequence polymorphism. One elephant was infected with Indo-Oceanic and East African–Indian (CAS-Delhi) lineages; the other was infected with Indo-Oceanic and East Asian (Beijing) lineages.

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Molecular characterization of Mycobacterium tuberculosis isolates from elephants of Nepal

Cited by 23 publications

References 26 publications

Wildlife Tuberculosis: An Emerging Threat for Conservation in South Asia

Wildlife Tuberculosis: An Emerging Threat for Conservation in South Asia

My life with elephants

MixedMycobacterium tuberculosisLineage Infection in 2 Elephants, Nepal

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