Molecular characterization of porcine TT virus, an orphan virus, in pigs from six different countries

McKeown, N. E.; Fenaux, Martijn; Halbur, Patrick G.; Meng, Xiang‐Jin

doi:10.1016/j.vetmic.2004.08.013

Cited by 100 publications

(92 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…TTV presence in domestic animals is also established and it was detected in dogs, cows, cats, chicken, sheep etc [37,79,80,135,137,138].…”

Section: Animal Torque Teno Virusmentioning

confidence: 99%

Current and Future Prospects of Torque Teno Virus

Elsaie¹

2013

J Vaccines Vaccin

View full text Add to dashboard Cite

Human health has a significant importance and it is directly affected by a number of factors like different diseases including microbial and viral infections. Up till now we have paid attention to the disease causing viruses and pathogens and less has been investigated about the usefulness of normal viral flora. One such orphan virus is Torque Teno Virus (TTV). The virus is present in healthy as well as diseased population, indicating its high prevalence. The virus is ubiquitous to human body as it is present in almost all tissues and organs and this is the property that can be utilized for targeted drug delivery. Another potentially useful property of this virus is TTV derived Apoptosis Inducing protein that can be a hope for the affectees.

show abstract

“…TTV presence in domestic animals is also established and it was detected in dogs, cows, cats, chicken, sheep etc [37,79,80,135,137,138].…”

Section: Animal Torque Teno Virusmentioning

confidence: 99%

Current and Future Prospects of Torque Teno Virus

Elsaie¹

2013

J Vaccines Vaccin

View full text Add to dashboard Cite

show abstract

“…Swine TTV has also shown worldwide distribution, and a high seropositive ratio in the general pig population has been reported. 13 To date, more than 25 genogroups of TTV have been identified in humans, 5 but only 3 fully sequenced swine TTV have been published. After the first finding of swine TTV in 2004, different genogroups in pigs were subsequently identified.…”

mentioning

confidence: 99%

“…After the first finding of swine TTV in 2004, different genogroups in pigs were subsequently identified. 13,15 Porcine TTV isolates Sd-TTV31 and Sd-TTV1p have a relatively high nucleotide sequence identity (69.6%) and are classified as TTV genogroup 1. Sd-TTV31, a prototype of genogroup 1, and Sd-TTV2p, a recently sequenced swine TTV, share a low nucleotide sequence identity (44%) with Sd-TTV31.…”

mentioning

confidence: 99%

Quantitative Detection of Porcine Torque Teno Virus in Porcine Circovirus-2–Negative and Porcine Circovirus–Associated Disease-Affected Pigs

et al. 2010

View full text Add to dashboard Cite

Abstract. Torque teno virus (TTV) is a recently identified virus that has a wide range of host tropisms from humans to shrews. Human TTV and Torque teno mini virus are distributed worldwide, and their high prevalence in human populations has been reported. Pigs have their own species-specific TTV, and like human TTV, a high prevalence of porcine TTV also has been reported. Despite its high prevalence, the role of TTVrelated disease or syndrome in humans and pigs has not been determined. In the swine industry, TTV is thought to be one of the agents that aggravate clinical manifestation of Porcine circovirus-associated disease (PCVAD), a newly emerging, economically devastating disease. The purpose of the current study was to quantify TTV viral load in serum obtained from Porcine circovirus-2-negative pigs and PCVAD-affected pigs with real-time quantitative polymerase chain reaction assays and to compare TTV viral load between these groups. Results of this study indicate that there are no statically remarkable differences in TTV viral load between the 2 groups, which indicates that TTV might not be an agent of aggravation in PCVAD.

show abstract

“…TTSuV is widely distributed in pig herds in a number of countries in Asia, Europe, and America (McKeown et al 2004, Niel et al 2005, Gallei et al 2010, Savic et al 2010, Pérez et al 2011, Leme et al 2012. TTSuV infection is found in both healthy and diseased pigs, and a number of studies have been performed to determine the importance of the virus and the role it plays in infectious diseases (Meng 2012).…”

Section: Introductionmentioning

confidence: 99%

Torque teno sus virus (TTSuV) infection at different stages of pig production cycle

Leme

Alfieri

2013

Pesq. Vet. Bras.

View full text Add to dashboard Cite

Pesq. Vet. Bras. 33 (7) It has been demonstrated that TTSuV might increase the severity of other important viral diseases with economic and public health impacts. At present, there is no information on the age distribution of pigs infected with TTSuV in Brazilian herds. This study evaluated the frequency of TTSuV infection in pigs at different stages of production. Fecal samples (n=190) from pigs at 1 to 24 weeks of age and from breeders at 6 farrow-to-weaning (up to 8 weeks of age) and 9 grower-to-finish (9 weeks of age onwards) farms in the western region of Paraná state, Brazil, were evaluated by PCR. Fragments of the 5' UTRs of TTSuV1 and/or TTSuVk2 DNAs were identified in 126 (66.3%) of the fecal samples. Significant differences were found with the percentages of positive samples for TTSuV1, TTSuVk2, and mixed infections by both genera between and within the different pig production stages. Fecal samples from the grower-to-finish farms had TTSuV detection rates (90.1%; 64/71) that were significantly (p<0.05) higher than those from the farrow-to-weaning farms (52.1%; 62/119). TTSuV detection was significantly (p<0.05) more frequent in finisher pigs than in the animals from the other stages. The UTR nucleotide sequences in this study presented higher similarities to strains from Norway (96%, TTSuV1), and Argentina and China (97.1%, TTSuVk2). These results suggest that TTSuV infection has spread to pigs of all production stages and that the viral infection rate increases with the age of the animals. In the western region of Paraná state, Brazil, TTSuV1 and TTSuVk2-induced infections were more frequently observed in suckling piglets and finisher pigs, respectively. Phylogenetic analysis pointed out the possibility of different strains of TTSuV1 and TTSuVk2 circulating in pig herds of Brazil. há informações sobre a distribuição da infecção pelo TTSuV, de acordo com a faixa etária, em rebanhos suinícolas brasileiros. Este estudo avaliou a frequência da infecção pelo TTSuV nas diferentes categorias de produção de suí-nos. Amostras fecais (n=190) de suínos com 1 a 24 semanas de idade e de reprodutores provenientes 6 unidades produtoras de leitão (até 8 semanas de idade) e 9 unidades de terminação (9 semanas de idade em diante) da região oeste do Paraná, Brasil, foram avaliadas pela técnica de PCR. Fragmentos da região 5' UTR do DNA do TTSuV1 e/ ou TTSuVk2 foram identificados em 126 (66,3%) amostras fecais. Diferenças significativas foram encontradas em relação às porcentagens de amostras positivas para o TTSuV1, Pesq. Vet. Bras. 33 (7)

show abstract

Molecular characterization of porcine TT virus, an orphan virus, in pigs from six different countries

Cited by 100 publications

References 16 publications

Current and Future Prospects of Torque Teno Virus

Current and Future Prospects of Torque Teno Virus

Quantitative Detection of Porcine Torque Teno Virus in Porcine Circovirus-2–Negative and Porcine Circovirus–Associated Disease-Affected Pigs

Torque teno sus virus (TTSuV) infection at different stages of pig production cycle

Contact Info

Product

Resources

About