Molecular characterization of potent antibacterial compound 4-(3-methylazetidin-1-yl)pentan-2-ol from Calophyllum inophyllum seed oil

Anjukam, Elamaran; Ramesh, Manickam; Rajalakshmi, Arumugam; Kavitha, K.; Prakash, Mani; Suresh, Gopal; Puvanakrishnan, Rengarajulu; Ramesh, Balasubramanian

doi:10.1016/j.bcab.2023.102617

Cited by 1 publication

(2 citation statements)

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“…The authors also reported the lowest and highest cytotoxicity value at LC 50 18.7% and 7.3%, respectively. The bioactive compound (4-(3-methylazetidin-1-yl) pentan-2-ol) of C. inophyllum seeds oil demonstrated potent antibacterial activities (17 ± 1.73 to 24 ± 1.15 mm) against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa [12]. Nguyen et al [9] isolated the bioactive calophyllolide compound from seeds and reported their anti-inflammatory and wound-healing activities.…”

Section: Major Bioactive Compounds Of C Inophyllum and Their Therapeu...mentioning

confidence: 99%

“…Flowers [7] Flavonoids, leucoantocyanins, anthocyanins, phenolic compounds, and tannins Anti-inflammatory and analgesic Seed [8] Calophyllolide Anti-inflammatory and wound healing Seeds [9] 4-(3-methylazetidin-1-yl) pentan-2-ol Anti-bacterial Seeds [12] Neoflavonoid Cell proliferation, glycosaminoglycan and collagen production, and wound healing Seeds [13] Palmitic acid, stearic acid, oleic acid, eicosanoic acid, squalene and linoleic acid. UV protection Seeds [14] Chromanone acid derivative (inocalophylline C), and calophyllolide -Seed (resin) [15] Table 1.…”

Section: Anti-bacterialmentioning

confidence: 99%

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The Extraction of Bioactive Agents from Calophyllum inophyllum L., and Their Pharmacological Properties

Ferdosh

2024

Sci. Pharm.

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Calophyllum inophyllum L. has been used for many generations by Pacific Islanders because of its numerous health and aesthetic advantages. The leaves, stems, roots, fruits, flowers, and seeds of this plant contain significant phytochemicals, including flavonoids, coumarins, fatty acids, and xanthones, which have been shown to have wound healing, analgesic, anti-inflammatory, antiaging, anti-arthritic, anti-cancer, anti-proliferative, anti-diabetic, anti-microbial, and anti-HIV effects. The chemical profiles and bioactive potential may vary due to different extraction techniques, plant parts, and geographical origins. Extraction is the essential first step in the analysis of bioactive compounds that leads to further separation, identification, and characterization. Conventional methods like maceration, Soxhlet, and percolation are often used to extract bioactive compounds from C. inophyllum. However, little study has been carried out on non-conventional methods such as pressured liquid extraction, supercritical fluid extraction (SFE), and ultrasound-assisted extraction. The SFE method can be used to extract bioactive compounds from C. inophyllum to retain their pharmacological properties for application in pharmaceutical and cosmetic products.

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Section: Major Bioactive Compounds Of C Inophyllum and Their Therapeu...mentioning

confidence: 99%

Section: Anti-bacterialmentioning

confidence: 99%

The Extraction of Bioactive Agents from Calophyllum inophyllum L., and Their Pharmacological Properties

Ferdosh

2024

Sci. Pharm.

View full text Add to dashboard Cite

show abstract

Molecular characterization of potent antibacterial compound 4-(3-methylazetidin-1-yl)pentan-2-ol from Calophyllum inophyllum seed oil

Cited by 1 publication

References 36 publications

The Extraction of Bioactive Agents from Calophyllum inophyllum L., and Their Pharmacological Properties

The Extraction of Bioactive Agents from Calophyllum inophyllum L., and Their Pharmacological Properties

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