Molecular characterization of prostate carcinoma tumor antigen-1, PCTA-1, a human Galectin-8 related gene

Gopalkrishnan, Rahul V.; Roberts, Thomas M.; Tuli, S.; Kang, Dong‐Chul; Christiansen, Keith A; Fisher, Paul B.

doi:10.1038/sj.onc.1203767

Cited by 51 publications

(45 citation statements)

References 60 publications

(64 reference statements)

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“…Primer extension analysis utilizing a 5 0 32 P-labeled reverse oriented primer starting at position 228 of AF095844 was performed with conditions described previously (Gopalkrishnan et al, 2000). A sequence reaction utilizing the same primer enabled precise identification of the transcriptional start site as an 'A' residue, 26 bp upstream of the 5 0 -end of AF095844 (data not shown).…”

Section: Effects Of Specific Mda-5 Domains On Cellular Growth and Surmentioning

confidence: 99%

Expression analysis and genomic characterization of human melanoma differentiation associated gene-5, mda-5: a novel type I interferon-responsive apoptosis-inducing gene

et al. 2003

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Section: Effects Of Specific Mda-5 Domains On Cellular Growth and Surmentioning

confidence: 99%

Expression analysis and genomic characterization of human melanoma differentiation associated gene-5, mda-5: a novel type I interferon-responsive apoptosis-inducing gene

et al. 2003

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“…Galectin-8/PCTA-1 is a newer and less characterized member of the family without clearly de®ned functions at the present time. Work within our own group and by others with the rat sequence has demonstrated a potential growth and metastasis suppressive function (Gopalkrishnan et al, 2000;Hadari et al, 2000).…”

Section: Prostate Stem Cell Antigen (Psca)mentioning

confidence: 91%

“…Monoclonal antibodies resulting from this process are used in expression screening of phage cDNA libraries to isolate the cDNA recognized by the respective antibody. PCTA-1 (Su et al, 1996), a molecule identi®ed using SEM, shows strong indications of playing a role in regulation of tumor spread (Gopalkrishnan et al, 2000).…”

Section: Methodologies To Identify Candidate Metastasis and Progressimentioning

confidence: 99%

“…This gene turned out to be a member of a family of galactose binding lectins or Galectins (speci®cally Galectin-8). The Galectins have diverse functions and apparently play a role in several cellular compartments and with distinct or overlapping but presently poorly understood physiological roles (Gopalkrishnan et al, 2000). Galectin-8/PCTA-1 is a newer and less characterized member of the family without clearly de®ned functions at the present time.…”

Section: Prostate Stem Cell Antigen (Psca)mentioning

confidence: 99%

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Molecular markers and determinants of prostate cancer metastasis

Gopalkrishnan

Kang

Fisher

2001

Journal Cellular Physiology

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Although intensely studied, the molecular and biochemical determinants of prostate cancer development and progression remain ill-de®ned. Moreover, current markers and methodologies cannot distinguish between a tumor that will remain indolent and not impinge on patient survival, versus a tumor with aggressive traits culminating in metastatic spread and death. Once prostate cancer is con®rmed the most signi®cant threat to a patient's survival and quality of life involves tumor metastasis. Radical surgery notwithstanding, prostate cancer accounts for 10% of all cancer-related deaths primarily arising through development of metastasis. Metastasis markers demonstrating an acceptable level of reliability are an obvious necessity if disproportionate and costly treatment is to be avoided and a reasonably accurate determination of clinical prognosis and measure of successful response to treatment is to be made. Therapeutic strategies that speci®cally inhibit metastatic spread are not presently possible and may not become available in the immediate future. This is because, while localized tumorigenesis has been relatively amenable to detection, analysis and treatment, metastasis remains a relatively unde®ned, complex and underexplored area of prostate cancer research. New ®ndings in the ®eld such subclasses of genes called metastasis suppressors and cancer progression suppressors, have opened up exciting avenues of investigation. We review current methodological approaches, model experimental systems and genes presently known or having potential involvement in human prostate cancer metastasis.

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“…It appears that PCTA-I expression is almost ubiquitous in normal human tissues and could alter in specific context such as transformation and metastasis (76). Galectin-8 is also reported to be a physiological modulator of cell adhesion.…”

Section: The Galectin Family Of Proteins and Metagenesismentioning

confidence: 99%

Characterization of lectins and their specificity in carcinomas—An appraisal

Sherwani

Mohmood

Khan

et al. 2003

Indian J Clin Biochem

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Lectins, a group of specific glycoproteins present in animal as well as plant cells, are used as differentiating markers to study cancers and metastatic cell lines. This property of lectins depends on the process of cellular glycosylation. Glycosylation of some of the extracellular membrane proteins and lipids maintains the cell/cell and cell/matrix interactions. Chemical alterations in glycosylation play an important role in the metastatic behavior of tumor cells. Carbohydrate residues of the membrane glycoproteins can be detected using lectins due to their binding specificity to carbohydrates. Lectins, therefore have gained an importance in the field of cancer research. Galectins, a specialized group of lectin like proteins that are Ca+ independent and galactoside binding, are also considered as differentiation markers in some specific cancers like the carcinomas of thyroid.Thus the use of lectins and galectins to identify specific carbohydrates present on cell surface help in invasion and metastasis processes.

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Molecular characterization of prostate carcinoma tumor antigen-1, PCTA-1, a human Galectin-8 related gene

Cited by 51 publications

References 60 publications

Expression analysis and genomic characterization of human melanoma differentiation associated gene-5, mda-5: a novel type I interferon-responsive apoptosis-inducing gene

Expression analysis and genomic characterization of human melanoma differentiation associated gene-5, mda-5: a novel type I interferon-responsive apoptosis-inducing gene

Molecular markers and determinants of prostate cancer metastasis

Characterization of lectins and their specificity in carcinomas—An appraisal

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