Molecular characterization of Staphylococcus argenteus in Myanmar: identification of novel genotypes/clusters in staphylocoagulase, protein A, alpha-haemolysin and other virulence factors

Aung, Meiji Soe; San, Thida; San, Nilar; Oo, Win Mar; Ko, Phyoe May; Thet, Khin Thet; Urushibara, Noriko; Kawaguchiya, Mitsuyo; Sumi, Ayako; Kobayashi, Nobumichi

doi:10.1099/jmm.0.000869

Cited by 20 publications

(20 citation statements)

References 46 publications

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“…The results suggest that these two tests also could be screening phenotypes for S. argenteus . In the present study, all 96 S. argenteus isolates with bacteremia were methicillin-susceptible and comparable to recent reports from Thailand, Japan, and Myanma, while isolates from Europe and Australia were more methicillin-resistant [ 5 , 10 , 14 , 15 , 16 ].…”

Section: Discussionsupporting

confidence: 91%

“…Previous studies have indicated that S. argenteus is generally more susceptible to antibiotics compared to S. aureus. [ 15 ] Some S. argenteus isolates may harbor virulence factors such as Panton-Valentine leucocidin (PVL) or enterotoxin (-like) genes [ 4 , 10 , 14 , 15 , 16 , 17 ]. S. argenteus has been isolated in Taiwan as reported by Chen et al [ 8 , 9 ] and Chu et al [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Heterogeneity of Molecular Characteristics among Staphylococcus argenteus Clinical Isolates (ST2250, ST2793, ST1223, and ST2198) in Northern Taiwan

et al. 2020

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Staphylococcus argenteus is an emerging pathogen that is recognized as non-pigmented Staphylococcus aureus. However, the molecular characteristics of S. argenteus and its virulence factors have not been well studied. The present study analyzed 96 isolates of S. argenteus recovered from blood. Identification of S. argenteus was based on results of MALDI-TOF MS and lacking crtM gene. All 96 isolates were methicillin-susceptible. Multilocus sequence typing (MLST) revealed four sequence types: ST2250 (n = 72), ST2793 (n = 12), ST1223 (n = 10), and ST2198 (n = 2). All 72 ST2250 isolates harbored CRISPR loci with polymorphism of direct repeats and spacers, but no other STs carried CRISPR loci. To date, ST2793 isolates have rarely been reported in other countries. Collagen-binding adhesin gene (cna) and staphylococcal enterotoxin type C (sec) were detected in 12 (100%) and 8 (67%) ST2793 isolates, respectively. ST1223 has been reported as food poisoning pathogens, and enterotoxin gene clusters (egc) were detected in all 10 isolates, while seb gene was detected in three isolates. Two ST2198 isolates carried bone sialoprotein-binding protein gene (bbp), belonging to agr type IV. Our focus on the heterogeneity of molecular characterization in four ST types of S. argenteus revealed that S. argenteus had been isolated as early as 2000. Each ST type of S. argenteus harbors particular genetic markers that may contribute to their virulence.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Heterogeneity of Molecular Characteristics among Staphylococcus argenteus Clinical Isolates (ST2250, ST2793, ST1223, and ST2198) in Northern Taiwan

et al. 2020

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“…aureus genetically and has recently been defined as a part of the S . aureus complex (SAC) (Aung et al, 2019; Jiang et al, 2018). In this study, we identified S .…”

Section: Resultsmentioning

confidence: 99%

“…We observed that of 70 S. aureus isolates, 11 were of S. argenteus, which is a novel staphylococcal species that is closely related to S. aureus genetically and has recently been defined as a part of the S. aureus complex (SAC) (Aung et al, 2019;Jiang et al, 2018). In this study, we identified S. argenteus using MLST analysis because the species cannot be distinguished from S. aureus through conventional microbiological identification methods.…”

Section: Molecular Characterization Of S Aureus Isolatesmentioning

confidence: 99%

Molecular characterization of clinical isolates from vascular access infection: A single‐institution study

et al. 2020

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“…S. argenteus has its own virulence factors that are genetically dissimilar to those of S. aureus, and this species appears adept at acquiring toxin and antibiotic resistance genes from its environment, increasing its pathogenicity (6). That said, neither vancomycin nor daptomycin resistance has previously been reported in S. argenteus isolates.…”

Section: Treatment and Outcomementioning

confidence: 99%

Genomic Profiling of Evolving Daptomycin Resistance in a Patient with Recurrent Staphylococcus argenteus Sepsis

Hao

Abdelghany

Lyden

et al. 2020

Antimicrob Agents Chemother

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Staphylococcus argenteus is a novel staphylococcal species associated with invasive disease. We report the first case of daptomycin/vancomycin-resistant S. argenteus, initially speciated as S. aureus, that developed from repeated treatment with daptomycin for a complex vascular graft infection. Whole genome sequencing of longitudinally collected isolates identified acquisition of MprF S337L, a mutation predicted to increase surface charge and repel cationic molecules.

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Molecular characterization of Staphylococcus argenteus in Myanmar: identification of novel genotypes/clusters in staphylocoagulase, protein A, alpha-haemolysin and other virulence factors

Cited by 20 publications

References 46 publications

Heterogeneity of Molecular Characteristics among Staphylococcus argenteus Clinical Isolates (ST2250, ST2793, ST1223, and ST2198) in Northern Taiwan

Heterogeneity of Molecular Characteristics among Staphylococcus argenteus Clinical Isolates (ST2250, ST2793, ST1223, and ST2198) in Northern Taiwan

Molecular characterization of clinical isolates from vascular access infection: A single‐institution study

Genomic Profiling of Evolving Daptomycin Resistance in a Patient with Recurrent Staphylococcus argenteus Sepsis

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