Molecular characterization of Streptococcus agalactiae in diseased farmed tilapia in China

Zhang, Defeng; Li, Aihua; Guo, Yaqiong; Zhang, Qianqian; Xue-nian, Chen; Gong, Xun

doi:10.1016/j.aquaculture.2013.07.014

Cited by 43 publications

(24 citation statements)

References 27 publications

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“…Serotype Ia/ST7 has been associated with large outbreaks of streptococcosis in cultured tilapia in China ( 9 ). The pathogenicity of human ST7 isolates in fish has been well established ( 10 ).…”

Section: The Studymentioning

confidence: 99%

Hypervirulent Clone of Group BStreptococcusSerotype III Sequence Type 283, Hong Kong, 1993–2012

Ip¹,

Ang²,

Fung³

et al. 2016

Emerg. Infect. Dis.

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Section: The Studymentioning

confidence: 99%

Hypervirulent Clone of Group BStreptococcusSerotype III Sequence Type 283, Hong Kong, 1993–2012

Ip¹,

Ang²,

Fung³

et al. 2016

Emerg. Infect. Dis.

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“…Streptococcus agalactiae is a Gram‐positive coccus, known as Group B Streptococcus (GBS), which has been recognized as a pathogen of humans, cattle, camels, dogs, hamsters, horses, monkeys and fish species (Bowater et al, ). GBS infections have been reported in many aquatic animals, such as Nile tilapia ( Oreochromis niloticus ) (Li et al, ; Ye et al, ; Zhang et al, ), barcoo grunter ( Scortum barcoo ) (Liu et al, ), golden pompano ( Trachinotus ovatus L.) (Cai et al, ), silver pomfret ( Pampus argenteus ) (Duremdez, Al‐Marzouk, Qasem, Al‐Harbi, & Gharabally, ), ya‐fish ( Schizothorax prenanti ) (Geng et al, ), giant Queensland grouper ( Epinephelus lanceolatus ) (Bowater et al, ) and bighead carp ( Aristichthys nobilis ) (Zhang et al, ). GBS can cause septicaemia and meningitis in farmed and wild fish, resulting in huge economic losses due to high mortality rates.…”

Section: Introductionmentioning

confidence: 99%

Capsular polysaccharide of Streptococcus agalactiae is an essential virulence factor for infection in Nile tilapia (Oreochromis niloticus Linn.)

Zhang

Liu

et al. 2018

Journal of Fish Diseases

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Streptococcus agalactiae (Group B Streptococcus, GBS) is associated with diverse diseases in aquatic animals. The capsule polysaccharide (CPS) encoded by the cps gene cluster is the major virulence factor of S. agalactiae; however, limited information is available regarding the pathogenic role of the CPS of serotype Ia piscine GBS strains in fish. Here, a non‐encapsulated mutant (Δcps) was constructed by insertional mutagenesis of the cps gene cluster. Mutant pathogenicity was evaluated in vitro based on the killing of whole blood from tilapia, in vivo infections, measuring mutant survival in tilapia spleen tissues and pathological analysis. Compared to wild‐type (WT) GBS strain, the Δcps mutant had lower resistance to fresh tilapia whole blood in vitro (p < 0.01), and more easily cleared in tilapia spleen tissue, and was highly attenuated in tilapia and zebrafish. Additionally, compared to the Δcps mutant, numerous GBS strains and severe tissue necrosis were observed in the tilapia spleen tissue infected with WT strains. These results indicated that the CPS is essential for GBS pathogenicity and may serve as a target for attenuation in vaccine development. Gaining a better understanding of the role, the GBS pathogenicity in fish will provide insight into related pathogenesis and host–pathogen interactions.

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“…However, diseases have become a major problem in the production of tilapia, and resulted in severe economic loss [6]. Streptococcus agalactiae is a Gram-positive bacterium causing diseases in many fish species [8,9], including tilapia [10].…”

Section: Introductionmentioning

confidence: 99%

Characterization of the duodenase-1 gene and its associations with resistance to Streptococuus agalactiae in hybrid tilapia (Oreochromis spp.)

Shen

Liu

et al. 2015

Fish & Shellfish Immunology

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Molecular characterization of Streptococcus agalactiae in diseased farmed tilapia in China

Cited by 43 publications

References 27 publications

Hypervirulent Clone of Group BStreptococcusSerotype III Sequence Type 283, Hong Kong, 1993–2012

Hypervirulent Clone of Group BStreptococcusSerotype III Sequence Type 283, Hong Kong, 1993–2012

Capsular polysaccharide of Streptococcus agalactiae is an essential virulence factor for infection in Nile tilapia (Oreochromis niloticus Linn.)

Characterization of the duodenase-1 gene and its associations with resistance to Streptococuus agalactiae in hybrid tilapia (Oreochromis spp.)

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