Molecular characterization of the equine testis-specific protein 1 ( TPX1 ) and acidic epididymal glycoprotein 2 ( AEG2 ) genes encoding members of the cysteine-rich secretory protein (CRISP) family

Genome-wide association study for semen quality traits in German Warmblood stallions

“…CRISPs are predominantly expressed in the male genital tract and secreted into the seminal plasma. It has been shown that all three CRISP genes exhibit considerable variation between stallions (Giese et al, 2002). CRISP1 is primarily expressed in the epididymis where it potentially plays a role during the sperm-oocyte fusion via protein binding to the sperm surface (Cohen et al, 2000).…”

Integration of high-resolution array comparative genomic hybridization analysis of chromosome 16q with expression array data refines common regions of loss at 16q23–qter and identifies underlying candidate tumor suppressor genes in prostate cancer

“…Expression of the candidate gene Q9H0B8 is shown on separate axes due to the greater level of expression of this gene. Significance values were calculated using a matched pair t-test aCGH and expression analysis of 16q in prostate cancer JEV Watson et al 1-3 are expressed primarily in the male genital tract and are thought to mediate cell-cell interactions with other cells during sperm maturation or during fertilization (Giese et al, 2002). Downregulation of Q9H0B8 expression may therefore be a marker for de-differentiation of prostate cells.…”

Genome-wide germline-enriched and sex-biased expression profiles in Caenorhabditis elegans

“…Named genes among the hermaphrodite soma-biased gene set include lin-2, sir-2.2, egl-13 and the genes encoding vitellogenin. Among the most highly male soma-biased genes are several that are similar to Tpx1, a vertebrate gene required for male germ cell interaction with surrounding somatic tissue in vertebrates (Giese et al, 2002). We also found 12 genes encoding neuropeptide-like proteins (nlp-1-3, -12, -14, -25, -31 and flp-3, -6, -8, -9) with malebiased expression that could potentially be involved in mediating male-specific behaviors.…”