Molecular classification of carcinoma of unknown primary by gene expression profiling from formalin-fixed paraffin-embedded tissues

Gene Expression Profiling of Renal Cell Carcinoma

“…This requirement also severely limits tissue available for research. To address this, expression microarrays customized for formalin-fixed paraffin-embedded tissue have been constructed (53). Should the utility of these arrays be borne out in large-scale studies, large numbers of tissue specimens with defined clinical conditions and outcomes would be immediately available for clinical research.…”

Unraveling the genetics of atherosclerosis: implications for diagnosis and treatment

“…The genes themselves can be used to develop a diagnostic or prognostic test. There are currently several commercially available prognostic and diagnostic tests based on gene expression; two for predicting breast cancer recurrence, one for diagnosing cancers of unknown primary and one for detecting early cardiac transplant rejection [44][45][46][47].…”

Genomic, targeted therapy and CUP: towards a management based on the molecular analysis of the CUP?

“…Considé rant que les cellules qui mé tastasent à distance conservent les caracté ristiques d'expression gé nique de leur site d'origine [11], plusieurs é quipes se sont logiquement inté ressé es à la mise en é vidence de profils d'expression gé nique du tissu spé cifique de la tumeur primitive, grâ ce aux techniques actuelles de gé nomique à haut-dé bit. Le principe de ces techniques ré side dans la dé termination d'une signature molé culaire à partir de l'ARN extrait de la mé tastase comparé e à celle de tumeurs primitives connues.…”