Molecular classification of infiltrating ductal carcinomas in Western Algeria

Abstract

Introduction: Breast carcinoma is a heterogeneous pathology. These subtypes are known to vary in terms of risk factors, natural histories and responses to therapies. The prognostic classification based on gene expression and genomic profiling was implemented to refine therapeutic indications and improve patient survival. Our goal is to classify infiltrating channel carcinomas according to their molecular profiles and analyze the different clinicopathological variables of these molecular groups. Material and methods: We conducted a 24-month retrospective study involving 50 patients recruited from the Oran University Hospital and the Oran Regional Military Hospital. Tumors were analyzed histologically and classified after an immunohistochemical study in groups: luminal A, luminal B, Her2+ and basal-like. Results: Our study showed the predominance of molecular subtype luminal B (36%) of which 55.56% of these tumors were of Scarff-Bloom-Richardson (SBR) grade II and 44% were of grade III. 55.56% were T2 size followed by T1 size with a percentage of about 33.33%. Axillary ganglionic metastases were found in 88.89% of cases, followed by luminal A (32%) with 62.5% grade III, and 37.5% grade SBR II. Thus 37.5% of these tumors were of stage T2 and T4. Axillary ganglionic metastases were present in 87.5%. The HER2 type (20%) with 60% SBR II grade and 40% grade III. All basal-like tumors represented the highest SBR grade III with a percentage of 100%. Conclusions: Molecular classification is crucial in the direction of treatment.