Molecular Clock Genes in Man and Lower Animals Possible Implications for Circadian Abnormalities in Depression

Bunney, William E.

doi:10.1016/s0893-133x(99)00145-1

Cited by 240 publications

(154 citation statements)

References 96 publications

Supporting

Mentioning

150

Contrasting

Unclassified

Order By: Relevance

“…These results are similar to those a b reported for other animal models of depression (Overstreet, 1993;Solberg et al, 2001) and are reminiscent of the behavioural inhibition and the global flattening of circadian rhythms observed in depressed patients (Bunney and Bunney, 2000;Souetre et al, 1989). In NH mice, the changes in core temperature across the 24 h period were directly correlated with those of locomotor activity (Bunney and Bunney, 2000). In contrast, in H mice, the core temperature was lower than in NH mice during the light period, but it rose to NH levels during the dark period.…”

Section: Locomotor Activity and Sleep-wakefulness Cycles Under Baselisupporting

confidence: 91%

“…In contrast, in H mice, the core temperature was lower than in NH mice during the light period, but it rose to NH levels during the dark period. Interestingly, depressed patients also exhibit disruptions of the body temperature rhythm (Avery et al, 1999;Bunney and Bunney, 2000).…”

Section: Locomotor Activity and Sleep-wakefulness Cycles Under Baselimentioning

confidence: 99%

“…It is associated with characteristic sleep impairments, notably difficulties in falling asleep, reduction of the rapid eye movement (REM) sleep latency, sleep fragmentation, and early morning awakenings (Adrien, 2002;Benca, 2000). In addition, abnormalities of circadian rhythms, affecting notably nycthemeral variations in rest-activity, and body temperature, have been described in depressed patients (Avery et al, 1999;Bunney and Bunney, 2000;Souetre et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Homeostatic Regulation of Sleep in a Genetic Model of Depression in the Mouse: Effects of Muscarinic and 5-HT1A Receptor Activation

Popa

Yacoubi²,

Vaugeois³

et al. 2005

Neuropsychopharmacol

View full text Add to dashboard Cite

In depressed patients, sleep undergoes marked alterations, especially sleep onset insomnia, sleep fragmentation, and disturbances of the Rapid Eye Movement (REM) sleep. Abnormalities of rest-activity rhythms and of hypothalamic-pituitary-adrenocortical function have also been described in these patients. In the present study, we examined the presence of such abnormalities in a recently developed line of mice (Helpless mice-H) that exhibit depression-like behaviors in validated tests, compared to the nonhelpless (NH) line derived from the same colony. Experiments were essentially carried out in females for which previous studies showed marked differences between H and NH lines. Compared to NH mice, the H line exhibited (i) lower basal locomotor activity, (ii) sleep fragmentation, shift towards lighter sleep stages, and facilitation of REM sleep reflected by increased amounts and decreased latency, (iii) larger response to the REM sleep promoting effect of muscarinic receptor stimulation (by arecoline). In contrast, H and NH mice were equally responsive to the REM sleep inhibitory effect of 5-HT 1A receptor stimulation (by 8-OH-DPAT). In addition, a deficiency in delta power enhancement after sleep deprivation was observed in the H group, and acute immobilization stress in this group failed to elicit a REM sleep rebound and was associated with a long-lasting raise in serum corticosterone levels. These results further validate H mice as a depression model and suggest they might be of particular interest for investigating the neurobiological mechanisms and possibly genetic substrates underlying sleep alterations associated with depression.

show abstract

Section: Locomotor Activity and Sleep-wakefulness Cycles Under Baselisupporting

confidence: 91%

Section: Locomotor Activity and Sleep-wakefulness Cycles Under Baselimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Homeostatic Regulation of Sleep in a Genetic Model of Depression in the Mouse: Effects of Muscarinic and 5-HT1A Receptor Activation

Popa

Yacoubi²,

Vaugeois³

et al. 2005

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…Some symptoms of MDD may show diurnal variations (mood, psychomotor activity, accessibility of memories of positive and negative experiences), and a subgroup of patients with MDD may have a circadian rhythm disorder (Bunney and Bunney, 2000). In healthy young subjects, moderate changes in the timing of the sleep-wake cycle had specific effects on subsequent mood (Boivin et al, 1997).…”

Section: Diurnal Variationmentioning

confidence: 99%

“…In healthy young subjects, moderate changes in the timing of the sleep-wake cycle had specific effects on subsequent mood (Boivin et al, 1997). The association between phase advance of the sleep-wake cycle and phase advances in nocturnal cortisol secretion, and the effect of antidepressants on circadian rhythms of behavior, physiology, and endocrinology contribute to the biological plausibility of this putative endophenotype (Duncan, 1996;Bunney and Bunney, 2000). Because manipulations of the circadian rhythms (light therapy, sleep deprivation, phase advance treatment) can have antidepressant efficacy, circadian abnormalities have been hypothesized to be etiologically associated with major depression.…”

Section: Diurnal Variationmentioning

confidence: 99%

Discovering Endophenotypes for Major Depression

Hasler

Drevets

Manji

et al. 2004

Neuropsychopharmacol

1,026

739

View full text Add to dashboard Cite

The limited success of genetic studies of major depression has raised questions concerning the definition of genetically relevant phenotypes. This paper presents strategies to improve the phenotypic definition of major depression by proposing endophenotypes at two levels: First, dissecting the depressive phenotype into key components results in narrow definitions of putative psychopathological endophenotypes: mood bias toward negative emotions, impaired reward function, impaired learning and memory, neurovegetative signs, impaired diurnal variation, impaired executive cognitive function, psychomotor change, and increased stress sensitivity. A review of the recent literature on neurobiological and genetic findings associated with these components is given. Second, the most consistent heritable biological markers of major depression are proposed as biological endophenotypes for genetic studies: REM sleep abnormalities, functional and structural brain abnormalities, dysfunctions in serotonergic, catecholaminergic, hypothalamic-pituitary-adrenocortical axis, and CRH systems, and intracellular signal transduction endophenotypes. The associations among the psychopathological and biological endophenotypes are discussed with respect to specificity, temporal stability, heritability, familiality, and clinical and biological plausibility. Finally, the case is made for the development of a new classification system in order to reduce the heterogeneity of depression representing a major impediment to elucidating the genetic and neurobiological basis of this common, severe, and often life-threatening illness.

show abstract

Bright Light Treatment in Elderly Patients With Nonseasonal Major Depressive Disorder

Lieverse¹,

Someren²,

Nielen³

et al. 2011

Arch Gen Psychiatry

228

154

View full text Add to dashboard Cite

show abstract

Molecular Clock Genes in Man and Lower Animals Possible Implications for Circadian Abnormalities in Depression

Abstract: This paper reviews the recent discovery of clock genes that

Cited by 240 publications

References 96 publications

Homeostatic Regulation of Sleep in a Genetic Model of Depression in the Mouse: Effects of Muscarinic and 5-HT1A Receptor Activation

Homeostatic Regulation of Sleep in a Genetic Model of Depression in the Mouse: Effects of Muscarinic and 5-HT1A Receptor Activation

Discovering Endophenotypes for Major Depression

Bright Light Treatment in Elderly Patients With Nonseasonal Major Depressive Disorder

Contact Info

Product

Resources

About