Molecular Clonality Testing

Seelig, Davis; Avery, Anne C.

doi:10.1002/9781119380559.ch9

Cited by 1 publication

(1 citation statement)

References 41 publications

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“…False-positive PARR results are described in non-neoplastic monoclonal lymphoid expansions (ie, benign clonal lymphoid proliferations) and non-lymphoid neoplasms. 19 Benign clonal lymphoid expansions are reported in feline inflammatory bowel disease (IBD) and Erlichia species infection. 20 , 21 Therefore, a marked suppurative process of the tympanic bulla could have caused a benign clonal lymphoid proliferation, as reported in cases of feline IBD.…”

Section: Discussionmentioning

confidence: 99%

Clinical features, MRI findings and outcome of a primary extranodal B-cell lymphoma affecting the tympanic bulla treated with chemotherapy alone

Silva,

Fadda,

Paran

et al. 2023

Journal of Feline Medicine and Surgery Open Reports

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Case summaryA 2-year-old neutered female feline leukaemia virus (FeLV)-negative domestic shorthair cat was referred with an acute onset of vestibular signs. A clinical examination identified evidence of otitis externa of the right ear and enlargement of the right mandibular lymph node. MRI revealed predominantly T2 and FLAIR hyperintense and contrast-enhancing lesions affecting the right external ear canal, tympanic bulla and nasopharyngeal regions with intracranial extension. Cytology and culture and sensitivity samples collected from the middle ear via myringotomy revealed a population of intermediate to large lymphocytes consistent with lymphoma and mixed Staphylococcus chromogenes and Pasteurella species infection. PCR for antigen receptor rearrangements on the ear cytology was consistent with a B-cell rearrangement. A primary extranodal B-cell lymphoma affecting the tympanic bulla and other sites with secondary septic otitis media and interna was diagnosed. After the improvement of clinical conditions after corticosteroid, antibiotic and chemotherapy treatment, the cat was alive 22 months after diagnosis without recurrence of clinical signs.Relevance and novel informationThis is the first report of a primary extranodal B-cell lymphoma affecting the tympanic bulla with suspected involvement of the nasopharynx and cranial vault treated with chemotherapy alone in the veterinary literature. Although very rare, B-cell lymphoma should be included in the differentials for diseases affecting the inner and/or middle ear and extending intracranially in cats. Chemotherapy represents a non-invasive treatment modality with a survival of up to 22 months appearing possible.

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Section: Discussionmentioning

confidence: 99%