Molecular Cloning and Characterization of a Novel Human Gene Containing Ankyrin Repeat and Double BTB/POZ Domain

Dai, Ken-Shwo; Wei, Wei; Liew, Choong‐Chin

doi:10.1006/bbrc.2000.3053

Cited by 13 publications

(12 citation statements)

References 31 publications

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“…Because PINK1 mRNA is expressed ubiquitously among adult tissues examined, the PINK1 gene may play important fundamental roles in cell. When we isolated the fulllength cDNA of the second EST, we noticed that the sequence was identical to BPOZ (Dai et al, 2000), a gene that contains an ankyrin repeat and two BTB/ POZ domains.…”

Section: Discussionmentioning

confidence: 99%

“…Identification of splicing variants of BPOZ During our process of isolating a full-length cDNA for the other EST, Dai et al (2000) reported the same gene and termed it BPOZ, whose deduced product contained an ankyrin repeat and two BTB/POZ domains although its biological function was unknown. Our Northern-blot analysis revealed that the BPOZ transcript was approximately 2.0 kb long, and was expressed in all 16 human adult tissues examined (data not shown).…”

Section: Identification Of a Novel Pten-induced Putative Kinase Pink1mentioning

confidence: 99%

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Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway

2001

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Section: Discussionmentioning

confidence: 99%

Section: Identification Of a Novel Pten-induced Putative Kinase Pink1mentioning

confidence: 99%

Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway

2001

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“…The gene's product, expressed in fetal rather than adult tissues, is considered to be entangled in normal development, enhancing protein interconnections. Expression of this gene is activated by the phosphatase and tensin homolog, a tumor suppressor [6]. Alterations in the form of gains affecting the 6p22.2-22.1 region where this gene lies have been found in meningiomas [7].…”

Section: Genetics In Gep-netsmentioning

confidence: 99%

The Role of Genetics in Sporadic GEP-NETs: A Comprehensive Review of the Literature

Fotopoulos

Vathiotis

Nikou

et al. 2017

Forum of Clinical Oncology

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Neuroendocrine tumors (NETs) are composed of a heterogeneous group of malignancies from neuroendocrine cell compartments, with roles in both the endocrine and the nervous system. The majority of NETs are gastroenteropancreatic (GEP) in origin, arising in the foregut, midgut, or hindgut. The genomic landscape of GEP-NETs has been scarcely studied in terms of genomic profiling.The following algorithm was followed using the keywords neuroendocrine, genomics, targeted therapy, personalized medicine, gastroenteropancreatic and NET. The search was performed in PubMed and ScienceDirect database. Our current knowledge of sporadic GEP-NETs genetics must be further advanced to elucidate the molecular basis and pathogenesis of the disease, improve the accuracy of diagnosis, and guide tailor-made therapies.

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“…The BPOZ‐2 transcript is ubiquitously expressed in all fetal tissues examined (heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and blood leukocyte), suggesting that BPOZ‐2 is involved in basic cellular function. From the low expression of BPOZ‐2 in adult tissues (normal and hypertrophic heart), BPOZ‐2 gene expression is considered to be under developmental regulation (Dai et al. 2000; Unoki & Nakamura 2001).…”

Section: Introductionmentioning

confidence: 99%

TdT interacting factor 1 enhances TdT ubiquitylation through recruitment of BPOZ‐2 into nucleus from cytoplasm

et al. 2009

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We isolated human cDNA clone encoding Bood POZ containing gene type 2 (BPOZ-2) as a gene with a product that binds to TdT interacting factor 1 (TdIF1) using a yeast two-hybrid system. BPOZ-2 is an adaptor for E3 ligase CUL3 and participates in developmental processes. The binding between BPOZ-2 and TdIF1 was confirmed by GST pull-down and immunoprecipitation assays using specific antibodies against BPOZ-2 and TdIF1 in vitro and in vivo. Although when BPOZ-2 solely was expressed in COS7 cells, BPOZ-2 was observed mainly within the cytoplasm, co-transfection of pEGFP-BPOZ-2 and pDsRed-TdIF1 into COS7 cells resulted in co-localization of EGFP-BPOZ-2 and DsRed-TdIF1 within the nucleus. TdIF1 may recruit BPOZ-2 into the nucleus from the cytoplasm by directly binding to BPOZ-2. BPOZ-2 enhanced TdT ubiquitylation when TdIF1 was expressed together with BPOZ-2 in 293T cells, strongly suggesting that the recruitment of BPOZ-2 into the nucleus from the cytoplasm is significant for the TdT ubiquitylation within the nucleus.

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Molecular Cloning and Characterization of a Novel Human Gene Containing Ankyrin Repeat and Double BTB/POZ Domain

Cited by 13 publications

References 31 publications

Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway

Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway

The Role of Genetics in Sporadic GEP-NETs: A Comprehensive Review of the Literature

TdT interacting factor 1 enhances TdT ubiquitylation through recruitment of BPOZ‐2 into nucleus from cytoplasm

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