Molecular Cloning and Characterization of a New Insulin/IGF-like Peptide of the Nematode Caenorhabditis elegans

Life span extensions associated with upregulation of gene expression of antioxidant enzymes in Caenorhabditis elegans; studies of mutation in the age-1, PI3 kinase homologue and short-term exposure to hyperoxia

“…Location of DAF-18 PTEN in the pathway for regulating life span is yet not clear. It has been considered that activation of the DAF-2 insulin receptor by its ligand (17,18,19) leads to activation of AGE-1 PI3 kinase, which generates the phosphatidylinositol-3,4,5-triphosphate (PIP3), a second messenger (6). This second messenger activates the PDK-1 and AKT kinases (7,20 ), which antagonize the activity of DAF-16 transcription factor.…”

cDNA structure of an insulin-related peptide in the Pacific oyster and seasonal changes in the gene expression

“…Several peptides structurally related to insulin have also been identified in invertebrates including insects (Nagasawa et al 1986), mollusks (Smit et al 1988), nematodes (Kawano et al 2000) and chordates (McRory & Sherwood 1997). Among these invertebrate insulins, the physiological roles of the peptide have been studied most in insects.…”

“…In C. elegans, mutation of an insulin receptor family member, DAF-2, leads to the formation of the metabolically less active dauer, accompanied by developmental arrest and an increase in life span (Kimura et al 1997). Disruption of the production of the insulin/insulinlike growth factor-like peptide also results in an extended life span (Kawano et al 2000).…”

Lifespan Extending Activity of Substances Secreted by the NematodeCaenorhabditis elegansThat Include the Dauer-Inducing Pheromone

“…5,6) So far, 39 C. elegans genes encoding an insulin-like molecule have been identified, and a few of them have been proved to be relevant to the lifespan. [7][8][9] During our trial to isolate the dauer-inducing pheromone, we found by chance that crude extract including the pheromone extends the adult lifespan. Here we report the effect of the extract on longevity and the relevancy of insulin signaling to the lifespan extension caused by the extract.…”