2015
DOI: 10.1016/j.jbiosc.2015.02.019
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Molecular cloning and characterization of l-methionine γ-lyase from Streptomyces avermitilis

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Cited by 9 publications
(11 citation statements)
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“…The gen SCO1294 was up-regulated in S. coelicolor at 36 h. Even though this gene has not been studied in S. coelicolor , its homolog in S. avermitilis ( SAV7062 ) has been described as a L-methionine-γ-liase that degrades methionine, cysteine, and derivatives ( Kudou et al, 2015 ).…”
Section: Resultsmentioning
confidence: 99%
“…The gen SCO1294 was up-regulated in S. coelicolor at 36 h. Even though this gene has not been studied in S. coelicolor , its homolog in S. avermitilis ( SAV7062 ) has been described as a L-methionine-γ-liase that degrades methionine, cysteine, and derivatives ( Kudou et al, 2015 ).…”
Section: Resultsmentioning
confidence: 99%
“…It is made available under a preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in The copyright holder for this this version posted February 15, 2022. ; https://doi.org/10.1101/2022.02.14.480474 doi: bioRxiv preprint L-methionine can be converted to L-homocysteine, an important intermediate of the transsulfuration pathway, via two possible routes (Figure 1A). The first requires the catalytic action of a methionine γ-lyase (MγL) for degradation to 2-oxobutanoate, NH4 + , and methanethiol (9). The latter is then oxidized to sulfide, H2O2, and formaldehyde by a methyl mercaptan oxidase (MMO) present in Rhodococcus strain IGTS8 (10).…”
Section: The Methionine-cysteine Interconversion Pathways In Bacteriamentioning
confidence: 99%
“…L-methionine can be converted to L-homocysteine, an important intermediate of the transsulfuration pathway, via two possible routes ( Figure 1A ). The first requires the catalytic action of a methionine γ-lyase (MγL) for degradation to 2-oxobutanoate, NH 4 + , and methanethiol (9). The latter is then oxidized to sulfide, H 2 O 2 , and formaldehyde by a methyl mercaptan oxidase (MMO) present in Rhodococcus strain IGTS8 (10).…”
Section: Introductionmentioning
confidence: 99%
“…l ‐methionine γ‐lyase (MGL, EC 4.4.1.11), is a fold type I pyridoxal‐5’ ‐phosphate (PLP)‐dependent enzyme which can react with sulfur containing aminoacids such as methionine and cysteine toproduce α‐keto acids, ammonia, and volatile thiols by an α,γ‐elimination mechanism [6] . The presence of MGL has been reported in several organisms including plants, bacteria, fungi, actinomycetes and protozoa, except humans and its recombinant production on large scale is simple [7–9] .…”
Section: Introductionmentioning
confidence: 99%