Molecular cloning and characterization of the DNA of two papiilomaviruses from monkeys

Kloster, Bruce E.; Manias, Dawn A.; Ostrow, Ronald S.; Shaver, Mohammad; McPherson, Scott W.; Rangen, S.R.S.; Uno, Hideo; Faras, Anthony J.

doi:10.1016/0042-6822(88)90143-2

Cited by 44 publications

(27 citation statements)

References 19 publications

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“…We have included serum samples from animals previously tested for RhPV-I DNA (Ostrow et al, 1990). This included serum from the index male from which RhPV-1 was first isolated (Kloster et al, 1988). In some cases, only tissue or only serum samples were available from individual animals at the various locations.…”

Section: Methodsmentioning

confidence: 99%

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Serological and molecular evidence of rhesus papillomavirus type 1 infections in tissues from geographically distinct institutions

Ostrow¹,

Coughlin²,

McGlennen

et al. 1995

Journal of General Virology

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We have previously demonstrated the presence of rhesus monkey papillomavirus type 1 (RhPV-1), from molecular and pathological evidence, in a mating group within a single institution. We have now also obtained a number of fresh or archival tissues of rhesus monkeys from other geographically distinct institutions. Using PCR amplification, we observed two animals from one of these institutions and five animals from another which demonstrated RhPV-1 DNA sequences. In addition we molecularly cloned the E7, E2, E4, L2 and L1 genes of RhPV-1 into bacterial expression vectors. The fusion gene products were used to test for serological response to RhPV-1 antigens by Western blot analysis. Responses were observed in up to 52 % of the animals tested. While some serologically positive animals were also RhPV-1 DNA-positive, most were not.

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Section: Methodsmentioning

confidence: 99%

“…Rhesus papillomavirus type 1 (RhPV-1) was recently isolated from a male rhesus monkey (Maccaca mulatta) with a penile carcinoma (Kloster et al, 1988). Subsequently other animals at the same facility were tested for the presence of the virus by molecular and pathological techniques (Ostrow et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

Serological and molecular evidence of rhesus papillomavirus type 1 infections in tissues from geographically distinct institutions

Ostrow¹,

Coughlin²,

McGlennen

et al. 1995

Journal of General Virology

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“…It is interesting that a papillomavirus isolated from skin lesions of a colobus monkey is related to the human cutaneous viruses HPV-5 and -8 (Kloster et al, 1988), and a papillomavirus isolated from the papillary lesions of the oral cavity of pigmy chimpanzees is related to HPV-13 (Van Ranst et al, 1991), the agent of oral focal epithelial hyperplasia in humans (Pfister et al, 1983), suggesting a close relationship between anatomical site and virus type in monkeys and in humans. Resza et al (1991) have isolated a second papillomavirus from colobus monkeys, which transforms established cells with the same frequency as BPV-1; it is not known whether this virus can transform primary cells.…”

mentioning

confidence: 99%

Cell transformation by animal papillomaviruses

1992

Journal of General Virology

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“…The transformed cells were found to have integrated and partially deleted CgPV-l DNA, indicating parallels with the fate of HPV-16 and -18 in some cervical cancer cell lines . A different isolate from a cutaneous papilloma (c. guereza papillomavirus type 2; CgPV-2) was found to be extrachromosomal (Kloster et al, 1988) and a laryngeal carcinoma from a colobus monkey was found to contain nucleotide sequences very closely related to RhPV-l (Kloster et al, 1988). These lesions obviously indicate the potential for non-human primate models of papillomavirus-induced genital and laryngeal tumours.…”

Section: Primate Papillomavirusesmentioning

confidence: 97%

“…This virus can be transmitted sexually and has been associated with squamous cell carcinoma of the cervix and a carcinoma of the penis (Kloster et al, 1988;Ostrow et al, 1990). RhPV-l has similarities with the high-risk HPV-16 and -18, being integrated in tumour DNA, and has been detected in rhesus monkeys from several different geographical locations (Ostrow et al, 1995).…”

Section: Primate Papillomavirusesmentioning

confidence: 99%

In vitroand Animal Models for Antiviral Therapy in Papillomavirus Infections

Stanley

Masterson

Nicholls

1997

Antivir Chem Chemother

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SummaryThe need for antiviral therapies for papillomavirus infections is well recognized but the difficulties of reproducing the infectious cycle of papillomaviruses in vitro has hindered our understanding of virus-cell interactions and the regulation of viral gene expression during permissive growth. Recent advances in understanding the temporal expression and function of papillomavirus proteins. has enabled consideration of a targeted approach to papillomavirus chemotherapy and in particular the inhibition of viral replication by targeting the El and E2 proteins. There are in vitro culture systems available for the screening of new chemotherapeutic agents, since significant advances have been made with culture systems which promote epithelial differentiation in vitro. However, to date, there are no published data which show that virions generated in vitro can infect keratinocytes and initiate another round of replication in vitro. In vivo animal models are therefore necessary to assess the efficacy of antivirals in preventing and treating viral infection, particularly for the low-risk genital viruses which are on the whole refractory to culture in vitro. Although papillomaviruses affect a wide variety of hosts in a species-specific manner, the animals most useful for modelling papillomavirus infections include the rabbit, ox, mouse, dog, horse, primate and sheep. The ideal animal model should be widely available, easy to house and handle, be large enough to allow for adequate tissue sampling, develop lesions on anatomical sites comparable with those in human diseases and these lesions should be readily accessible for monitoring and ideally should yield large amounts of infectious virus particles for use in both in vivo and in vitro studies. The relative merits of the various papillomavirus animal models available in relation to these criteria are discussed.

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Molecular cloning and characterization of the DNA of two papiilomaviruses from monkeys

Cited by 44 publications

References 19 publications

Serological and molecular evidence of rhesus papillomavirus type 1 infections in tissues from geographically distinct institutions

Serological and molecular evidence of rhesus papillomavirus type 1 infections in tissues from geographically distinct institutions

Cell transformation by animal papillomaviruses

In vitroand Animal Models for Antiviral Therapy in Papillomavirus Infections

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