Molecular cloning and comparative analysis of immunoglobulin heavy chain genes from Phasianus colchicus, Meleagris gallopavo, and Coturnix japonica

Mucosal Immunoglobulins

“…The primary amino acid structures of α chains of human (both subclasses and allotypes), gorilla, chimpanzee, orangutan, gibbon, macaque, sooty mangabey, dog, pig, goat, sheep, horse, dolphin, bat, rabbit, mouse, rat, cow, possum, duckbill platypus, echnida, quail, pheasant, turkey, chicken, duck, goose, ostrich, alligator, and crocodile IgA have been obtained by amino acid and/or DNA sequence analyses, and IgA-like antibodies have been identified in leopard geckos Burnett et al, 1989;Kawamura et al, 1991Kawamura et al, , 1992Patel et al, 1995;Brown and Butler, 1994;Knight et al, 1984;Kratzin et al, 1975;Mansikka, 1992;Putnam et al, 1979;Torano and Putnam, 1978;Tsuzukida et al, 1979;Tucker et al, 1981;Yang et al, 1979;Brown et al, 1997;Belov et al, 2002;Lundquist et al, 2001;Wagner et al, 2003;White et al, 1998;Zhou et al, 2005Zhou et al, , 2006Scinicariello et al, 2006;Mancia et al, 2007;Deza et al, 2007;Choi et al, 2010;Vernersson et al, 2010;Butler et al, 2011;Huang et al, 2012;Guo et al, 2014;Cheng et al, 2013;Magadan-Mompo et al, 2013a). Aligned sequences of IgA from selected species are shown in Figure 3.…”

“…The genes for the heavy chain of IgA have been cloned from several species, including humans (Flanagan et al, 1984), nonhuman primates (Kawamura et al, 1989(Kawamura et al, , 1990Ueda et al, 1988;Scinicariello et al, 2006;Rogers et al, 2008), rodents (Tucker et al, 1981;Bruggemann et al, 1986), bats (Butler et al, 2011), pets and domesticated animals (Knight et al, 1988;Burnett et al, 1989;White et al, 1998;Brown and Butler, 1994;Wagner et al, 1997;Patel et al, 1995;Zhou et al, 2006), dolphins (Mancia et al, 2007), marsupials (Aveskogh and Hellman, 1998), monotremes (Belov et al, 2002;Vernersson et al, 2010), and birds (Mansikka, 1992;Magor et al, 1998;Choi et al, 2010;Huang et al, 2012;Guo et al, 2014), in some cases as part of species genome projects. Thus, DNA sequence information for IgA is available for a wide range of mammalian and an increasing number of bird species.…”

Three IgH isotypes, IgM, IgA and IgY are expressed in Gentoo penguin and zebra finch

“…The bursa of Fabricius is a critical immune-related organ involved in avian B cell development that is bird-specific [22, 23]. Previous studies have shown that there are only three IgH isotypes in birds (IgM, IgA and IgY) encoded by the Cμ, Cα and Cυ genes, respectively, and clear evidence has shown that the IgD-encoding gene is absent in chickens and ducks [11, 12, 24, 25]. However, in a recent study, one δ gene and two additional μ and υ genes were discovered in certain birds such as the ostrich and emu [4].…”

Immunoglobulin genes and diversity: what we have learned from domestic animals

“…IgY consists of four CH domains but contains no hinge region [41]. Interestingly, although both chickens and ducks express the intact 4-CH IgY form, a truncated IgY form lacking the last two CH domains, designated as IgY(ΔFc), is also expressed in ducks.…”