2018
DOI: 10.1007/s12088-018-0731-3
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Molecular Cloning and Identification of the 2′–5′ Oligoadenylate Synthetase 2 Gene in Chinese Domestic Pigs Through Bioinformatics Analysis, and Determination of Its Antiviral Activity Against Porcine Reproductive and Respiratory Syndrome Virus Infection

Abstract: An interferon-mediated antiviral protein, 2'-5' oligoadenylate synthetase 2, plays an important role in the antiviral response of interferons. In this study, 2'-5' oligoadenylate synthetase 2 genes were cloned from Chinese domestic pigs. Bioinformatics analysis revealed that the 2024-bp long open reading fame encodes 707 amino acids. There are two conserved regions in this protein: the nucleotidyltransferase domain, and the 2'-5' oligoadenylate synthetase domain (OAS). Genetic evolution analysis showed that th… Show more

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Cited by 4 publications
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“…Western blotting and Immunoprecipitation were carried out as described previously [39][40][41][42]. The primary antibodies were as follows: anti-FLAG monoclonal antibody (Bioss antibodies, Beijing, China, #bs-0879R), anti-Anti-β-actin Polyclonal Antibody (Solarbio, # K006153P), anti-GAPDH antibody (Solarbio, # K106389P), anti-OASL antibody (Abcam, Cambridge, MA.…”
Section: Western Blotting and Immunoprecipitationmentioning
confidence: 99%
“…Western blotting and Immunoprecipitation were carried out as described previously [39][40][41][42]. The primary antibodies were as follows: anti-FLAG monoclonal antibody (Bioss antibodies, Beijing, China, #bs-0879R), anti-Anti-β-actin Polyclonal Antibody (Solarbio, # K006153P), anti-GAPDH antibody (Solarbio, # K106389P), anti-OASL antibody (Abcam, Cambridge, MA.…”
Section: Western Blotting and Immunoprecipitationmentioning
confidence: 99%