Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5).

Campbell, Hugh D.; Tucker, William Q. J.; Hort, Yvonne; Martinson, Mary E.; Mayo, Garry; Clutterbuck, Elaine J.; Sanderson, Colin J.; Young, Ian G.

doi:10.1073/pnas.84.19.6629

Cited by 293 publications

(119 citation statements)

References 34 publications

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“…5 IL-5 also enhances secretion of IgA by precommitted B cells 6 and affects IgG production by antigenprimed B cells. 7 In addition, IL-5 stimulates the production of eosinophils in cultures of human bone marrow, 8 acts as a chemo-attractant for mature murine eosinophils and induces superoxide anion production. 9 Much less however is known about the activity of IL-5 in vivo.…”

Section: Discussionmentioning

confidence: 99%

Eosinophilia is attenuated in experimental colitis induced in IL-5 deficient mice

Stevceva

Pavli²,

Husband

et al. 2000

Genes Immun

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Tissue eosinophilia is a feature of idiopathic inflammatory bowel disease and other forms of colonic inflammation but it is not clear whether the role of eosinophils in the disease process is to contribute to tissue damage. Interleukin 5 (IL-5) stimulates production and activation of eosinophils in vitro and enhances immunoglobulin A (IgA) production. As very little is known about the function of IL-5 in the colon, the aim of this study was to assess its role in colonic inflammation. IL-5 deficient mice were studied using the dextran sulphate sodium (DSS)-induced colitis model and the results compared to a congenic IL-5+/+ strain. The absence of IL-5 resulted in reduction of tissue eosinophilia (P Ͻ 0.0001) but was not reflected in differences in the severity of the disease (P Ͼ 0.5) or in the extent of tissue damage in this model of colitis. Numbers of immunoglobulin-containing cells in IL-5 deficient mice were similar to those in the IL-5+ mice. We conclude that the main role of IL-5 in DSS-induced colonic inflammation is to attract a population of eosinophils which do not appear to contribute significantly to the initiation or development of tissue damage in this model of colitis. Genes and Immunity (2000) 1, 213-218.

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Section: Discussionmentioning

confidence: 99%

Eosinophilia is attenuated in experimental colitis induced in IL-5 deficient mice

Stevceva

Pavli²,

Husband

et al. 2000

Genes Immun

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“…In addition, eosinophilic diseases have been associated with TNF-a [17], IL-5 [18], IL-10 [19]. Furthermore, IL-5, TNF-aand eotaxin-3 were correlated with eosinophilia in IgG4-related disease [20].…”

Section: Discussionmentioning

confidence: 97%

A case of IgG4-related kidney disease complicated by eosinophilic lung disease

et al. 2014

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IgG4-related disease is a systemic chronic inflammatory disorder characterized by a high blood level of IgG4 and the organ injuries by marked infiltration of IgG4-positive plasma cells and fibrosis. A 71-year-old male was hospitalized for a cough, malaise and anorexia. IgG4-related disease was suspected due to marked elevation of the serum IgG4 level. However, on lung biopsy, only eosinophil infiltration was demonstrated with no plasma cell infiltration. Otherwise abdominal contrastenhanced CT showed mild enlargement of the bilateral kidneys and many differed contrasted areas and FDG PET-CT. Moreover, renal biopsy specimens showed typical tubulointerstitial nephritis with a large number of IgG4-positive plasma cells infiltration (the IgG4/IgG-positive cell rate, 89 %) and fibrosis. We diagnosed this patient as typical IgG4-related kidney disease. He was treated by the moderate dose of prednisolone (0.8 mg/kg/day) alone, and showed prompt response in the clinical condition, and both the lung and kidney lesions. In this case, it was useful for diagnosis of IgG4-related diseases to evaluate an image such as abdominal contrast-enhanced CT and FDG PET-CT. Our case might be one of the possible patterns of IgG4-related lung diseases. In addition, we thought that there might be an association between hypereosinophilia and IgG4-related kidney disease.

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“…Recent reports indicate that IL-5 is involved in the actions of eosinophils , promoting their terminal differentiation from precursors (5), its migration into tissue (6), facilitating the secretion of eosinophil products (3), and prolonging the survival of eosinophils in the tissue (2, 7). IL-4 induces IgE production, which is inhibited by interferon a and y(8), while IL-5 enhances IL-4-induced IgE synthesis (9). Glucocorticoids inhibit gene expression and the synthesis of several lymphokines, including IL-4 and IL-5 (10-13).…”

Section: Discussionmentioning

confidence: 99%

Serum Interleukin-5 Levels in a Case with Allergic Granulomatous Angiitis.

et al. 1997

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A 50-year-old womanwith allergic granulomatous angiitis (AGA)presented with an elevated serum interleukin-5 (IL-5) level upon admission to a hospital. Administration of prednisolone showed marked improvement of asthmatic symptoms, reduced eosinophil counts of peripheral blood, and normalized serum IL-5 levels. This is the first report describing an elevated serum level of IL-5 in AGA. The present findings suggest that IL-5 is involved in the pathogenesis of AGA. (Internal Medicine 36: 709-711, 1997)

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Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5).

Cited by 293 publications

References 34 publications

Eosinophilia is attenuated in experimental colitis induced in IL-5 deficient mice

Eosinophilia is attenuated in experimental colitis induced in IL-5 deficient mice

A case of IgG4-related kidney disease complicated by eosinophilic lung disease

Serum Interleukin-5 Levels in a Case with Allergic Granulomatous Angiitis.

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