1997
DOI: 10.1002/(sici)1096-9861(19971013)387:1<53::aid-cne5>3.0.co;2-m
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Molecular cloning of a cDNA encoding the neuropeptides APGWamide and cerebral peptide 1: Localization of APGWamide-like immunoreactivity in the central nervous system and male reproductive organs ofAplysia

Abstract: While much is known about the neural and endocrine mechanisms that control egg laying in the gastropod mollusk Aplysia, relatively little is known about the regulation of male reproductive activity in this simultaneous hermaphrodite. In the present study, we have cloned and sequenced a cDNA that encodes a precursor protein, the predicted posttranslational processing of which presumably generates nine copies of the neuropeptide Ala-Pro-Gly-Trp-NH2 (APGWamide), five connecting peptide sequences, and a C-terminal… Show more

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Cited by 51 publications
(49 citation statements)
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“…Although other species have anteriomedial 5-HT-immunoreactive cells, P. sibogae is the first species reported to have asymmetrically positioned 5-HT-immunoreactive cells on the right side. Bilaterally asymmetric populations of cells containing other transmitters have been reported in other gastropods and such cells have been shown or assumed to be involved in the control of male reproductive organs found on the right side only (Croll and Van Minnen 1992;Fan et al 1997;Li and Chase 1995;. Consistent with these findings, 5-HT-immunoreactive fibres have also been found in the penial complex of P. sibogae (D. M. Boudko and R. P. Croll, unpublished observations).…”
Section: -Ht Immunoreactivitysupporting
confidence: 57%
“…Although other species have anteriomedial 5-HT-immunoreactive cells, P. sibogae is the first species reported to have asymmetrically positioned 5-HT-immunoreactive cells on the right side. Bilaterally asymmetric populations of cells containing other transmitters have been reported in other gastropods and such cells have been shown or assumed to be involved in the control of male reproductive organs found on the right side only (Croll and Van Minnen 1992;Fan et al 1997;Li and Chase 1995;. Consistent with these findings, 5-HT-immunoreactive fibres have also been found in the penial complex of P. sibogae (D. M. Boudko and R. P. Croll, unpublished observations).…”
Section: -Ht Immunoreactivitysupporting
confidence: 57%
“…At present we do not know which part of the FCAP peptide is responsible for its bioactivity. The FCAP precursor predicts a number of acidic peptides, but such peptides are often, although not always (Fan et al, 1997;Brezden et al, 1999), degraded and may function to compensate for the basic nature of the processing sites.…”
Section: Discussionmentioning
confidence: 99%
“…The neuropeptide APGWamide is secreted by the anteromedial region of the right cerebral ganglion, the right pedal ganglion, the copulatory duct, and penial complex of males (de Lange and van Minnen 1998;Fan et al 1997). APGWamide contributes to male mating behavior (Koene et al 2000) as well as the activity of the penis retractor muscle and muscles involved in ejaculation (Li et al 1992;Vangolen et al 1995).…”
Section: Hormones Of the Reproductive Neuro-endocrine Cascadementioning
confidence: 99%