1995
DOI: 10.1182/blood.v86.7.2534.bloodjournal8672534
|View full text |Cite
|
Sign up to set email alerts
|

Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11

Abstract: Interleukin-11 (IL-11) is a stromal cell-derived cytokine with multiple biologic activities on lymphohematopoietic cells. It belongs to a family of pleiotropic and redundant cytokines that use the gp 130 transducing subunit in their high affinity receptors. By amplifying human cDNA libraries with oligonucleotide primers corresponding to the conserved WSXWS motif found in the hematopoietic cytokine receptor family, a novel cytokine receptor cDNA was identified that, based on high (82%) sequence homology with th… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

2
26
1

Year Published

1996
1996
2018
2018

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 72 publications
(29 citation statements)
references
References 1 publication
2
26
1
Order By: Relevance
“…IL11RA encodes an interleukin 11 receptor alpha subunit. It interacts with the coreceptor gp130 to form a signaling complex that enables phosphorylation of the intracellular tyrosine of gp130 . It allows balanced interactions between osteoblasts precursors and osteoclasts, hence promoting direct intramembranous ossification without cartilaginous template .…”
Section: Discussionmentioning
confidence: 99%
“…IL11RA encodes an interleukin 11 receptor alpha subunit. It interacts with the coreceptor gp130 to form a signaling complex that enables phosphorylation of the intracellular tyrosine of gp130 . It allows balanced interactions between osteoblasts precursors and osteoclasts, hence promoting direct intramembranous ossification without cartilaginous template .…”
Section: Discussionmentioning
confidence: 99%
“…A binding subunit for IL-11 displaying a similar homology level to IL-6R␣ and CNTFR␣ was recently isolated in the mouse and human (Hilton et al, 1994;Cherel et al, 1995). Since gp130 is also involved in the transducing machinery of IL-11, we aligned the amino acid sequences of CNTFR␣ and IL-11R␣.…”
Section: Fig 8 Mutant Cntfr3␣ Specifically Inhibits Cntf-dependent mentioning
confidence: 99%
“…CNTFR␣ shows 50 and 54% homology with the IL-6 receptor ␣ (IL-6R␣) and with the IL-11 receptor ␣ (IL-11R␣), respectively (Yamasaki et al, 1988;Hilton et al, 1994;Cherel et al, 1995). Two regions of the IL-6R␣ involved in its association with gp130 are conserved in the IL-11 and CNTF receptor ␣ subunits.…”
mentioning
confidence: 99%
“…IL‐11 belongs to a subfamily of the 4‐helix bundle cytokines including interleukin‐6 (IL‐6), leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF) and cardiotrophin‐1 (CT‐1) that signal via the common signal transducing receptor protein gp130 (for review see [8]). IL‐11 first binds to its specific α‐receptor subunit (IL‐11R) [9,10] and subsequently, the complex of IL‐11 and IL‐11R triggers the dimerization of gp130 [11] leading to activation of the Janus kinase (Jak)/signal transducer and activator of transcription (STAT) signal transduction pathway [12]. Both receptor components belong to the family of hematopoietic cytokine receptors which are characterized by the presence of at least one cytokine binding module (CBM) [13].…”
Section: Introductionmentioning
confidence: 99%
“…The extracellular part of the IL‐11R is proposed to consist of an Ig‐like domain (D1) followed by a single CBM (D2 and D3) [9]. Whereas gp130 is expressed ubiquitously [14], IL‐11R expression is more restricted [9,10]. Cells expressing gp130 but lacking membrane‐bound IL‐11R can be stimulated by the combination of IL‐11 and soluble IL‐11R (sIL‐11R) indicating that the cytoplasmic and transmembrane parts of IL‐11R are not required for signal transduction [15].…”
Section: Introductionmentioning
confidence: 99%