“…In humans, PCI mRNA is expressed in many tissues, including liver, kidney, pancreas, skin, and the male and female reproductive organs (Geiger 2007; Krebs et al 1999) while PCI protein was additionally found in different body fluids, including plasma, urine, synovial fluid, sweat, tears, milk, seminal plasma, Graaf follicle fluid, and cerebrospinal fluid (Laurell et al 1992). In rodents, PCI is predominantly expressed in the male and female reproductive organs (Uhrin et al 2000; Wagenaar et al 2000; Wakita et al 1998). In humans, the functional role in vivo was tested in venous thrombosis, where elevated levels of PCI constituted a mild risk factor for thrombosis (Meijers et al 2002) indicating that of the possible actions of PCI: anticoagulant by inhibition of coagulation enzymes, anti-antifibrinolytic by inhibition of the thrombin activatable fibrinolysis inhibitor (TAFI) activation by thrombin-thrombomodulin, anti-anticoagulant by inhibition of activated protein C and protein C activation by thrombomodulin, and antifibrinolytic by the inhibition of urokinase, the last two options predominate in vivo.…”