Molecular confirmation of infectious spleen and kidney necrosis virus (ISKNV) in farmed and imported ornamental fish in Australia

Mohr, Peter G.; Moody, Nicholas J. G.; Williams, Lynette M.; Hoad, John; Cummins, David; Davies, Kelly R.; Crane, Mark StJ

doi:10.3354/dao02896

Cited by 34 publications

(27 citation statements)

References 16 publications

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“…The results of this study enable a reassessment of index cases for megalocytivirus infection and provide the first evidence of TRBIV-like megalocytiviruses in ornamental fish species, as all previous molecular phylogenetic studies of megalocytiviruses from ornamental fish showed affinities with ISKNV (Song et al 2008, Weber et al 2009, Kurita & Nakajima 2012, Sriwanayos et al 2013, Subramaniam et al 2014, Mohr et al 2015, Nolan et al 2015. To the extent that the samples analysed in this investigation are representative, the lack of detection of ISKNV megalocytiviruses in ornamental fish prior to the mid-1990s (Fig.…”

Section: Discussionmentioning

confidence: 63%

Detection of infectious spleen and kidney necrosis virus (ISKNV) and turbot reddish body iridovirus (TRBIV) from archival ornamental fish samples

Go¹,

Waltzek²,

Subramaniam³

et al. 2016

Dis. Aquat. Org.

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Section: Discussionmentioning

confidence: 63%

Detection of infectious spleen and kidney necrosis virus (ISKNV) and turbot reddish body iridovirus (TRBIV) from archival ornamental fish samples

Go¹,

Waltzek²,

Subramaniam³

et al. 2016

Dis. Aquat. Org.

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“…Megalocytiviruses have been implicated to infect more than 50 fish species and currently threaten the aquaculture industry, causing great economic losses in China, Japan, Australia and South-East Asia (Jung-Schroers et al, 2016;Mohr et al, 2015;Rimmer et al, 2015;Wang et al, 2007). Earlier, the ISKNV virus restricted to countries like Korea, China, Singapore and Taiwan (Joon et al, 2008;Tanaka et al, 2014) and later reported from USA (Yanong & Waltzek, 2012), Japan (Tanaka et al, 2014), and entered Australia (Mohr et al, 2015;Rimmer et al, 2015) and Germany (Jung-Schroers et al, 2016) through the fish transportation. In the present investigation, the presence of exotic ISKNV was detected and identified from the retailers at different locations in Karnataka state, India.…”

Section: Discussionmentioning

confidence: 99%

First report of the infectious spleen and kidney necrosis virus (ISKNV) infection in ornamental fishes in India

Girisha

Kushala

Nithin

et al. 2020

Transbounding Emerging Dis

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Infectious spleen and kidney necrosis virus (ISKNV), a member of family iridoviridae, reported for the first time in a wide range of ornamental fish species in India.Significant mortalities during the year 2018-19 were reported from a number of retailers in the region with various clinical signs. The samples of moribund, dead and apparently healthy ornamental fishes were collected from retailers, located in three districts of Karnataka, India. Out of 140 fish samples, 16 samples (11.42%) repre-How to cite this article: Girisha SK, Kushala KB, Nithin MS, et al. First report of the infectious spleen and kidney necrosis virus (ISKNV) infection in ornamental fishes in India.

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“…In a histopathological manner, hypertrophic cells with large basophilic cytoplasmic inclusions can be found in internal organs (Gibson‐Kueh et al., ; He et al., ). Outbreaks have occurred most frequently in East and South‐East Asia (Subramaniam, Shariff, Omar, & Hair‐Bejo, ), although the international trade of ornamental fish has aided the spread of these viruses to Europe (Jung‐Schroers et al., ; Sriwanayos et al., ) and Australia (Mohr et al., ; Nolan, Stephens, Crockford, Jones, & Snow, ; Rimmer, Whittington, Tweedie, & Becker, ; Rimmer et al., ).…”

Section: Introductionmentioning

confidence: 99%

First description of a natural infection with spleen and kidney necrosis virus in zebrafish

Bermúdez

Losada

Azevedo

et al. 2018

Journal of Fish Diseases

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Zebrafish has become a popular research model in the last years, and several diseases affecting zebrafish research facilities have been reported. However, only one case of naturally occurring viral infections was described for this species. In 2015, infectious spleen and kidney necrosis virus (ISKNV) was detected in zebrafish from a research facility in Spain. Affected fish showed lethargy, loss of appetite, abnormal swimming, distention of the coelomic cavity and, in the most severe cases, respiratory distress, pale gills and petechial haemorrhages at the base of fins. Cytomegaly was the most relevant histopathological finding in organs and tissues, sometimes associated to degenerative and necrotic changes. ISKNV belongs to the relatively newly defined genus Megalocytivirus, family Iridoviridae, comprising large, icosahedral cytoplasmic DNA viruses. This is the first case of naturally occurring Megalocytivirus infection in zebrafish research facilities, associated with morbidity. The virus has been identified based on both pathologic and genetic evidence, to better understand the pathogenesis of the infection in zebrafish and the phylogenetic relationship with other iridoviruses. Given the ability of megalocytiviruses to cross-species boundaries, it seems necessary to implement stringent biosecurity practices as these infections may invalidate experimental data and have major impact on laboratory and cultured fish.

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Molecular confirmation of infectious spleen and kidney necrosis virus (ISKNV) in farmed and imported ornamental fish in Australia

Cited by 34 publications

References 16 publications

Detection of infectious spleen and kidney necrosis virus (ISKNV) and turbot reddish body iridovirus (TRBIV) from archival ornamental fish samples

Detection of infectious spleen and kidney necrosis virus (ISKNV) and turbot reddish body iridovirus (TRBIV) from archival ornamental fish samples

First report of the infectious spleen and kidney necrosis virus (ISKNV) infection in ornamental fishes in India

First description of a natural infection with spleen and kidney necrosis virus in zebrafish

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