Molecular Cytology Applications on Gynecological Cytology

Carozzi, Francesca; Negri, Giovanni; Sani, Cristina

doi:10.1007/978-3-319-74942-6_8

Cited by 2 publications

(4 citation statements)

References 128 publications

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“…Therefore, there is a strong need for biomarkers that may allow risk stratification of hrHPV-positive women with normal cytology. [71][72][73][74] Several ancillary techniques are potentially useful in triaging hrHPVpositive women to increase the specificity of the test. Other than HPV genotyping that was described above, other molecular markers include those involved in cell cycling (overexpression of p16, HPV viral load, and integration) and those related to epigenetic change (methylation of human and viral genes, and microRNA).…”

Section: Other Ancillary Molecular Testsmentioning

confidence: 99%

“…Nevertheless, there are up to 8% of hrHPV‐positive women with normal cytology have or will develop in the subsequent years a CIN2+ lesion. Therefore, there is a strong need for biomarkers that may allow risk stratification of hrHPV‐positive women with normal cytology 71–74 . Several ancillary techniques are potentially useful in triaging hrHPV‐positive women to increase the specificity of the test.…”

Section: Molecular Testing Of Hpv In Gynecologic Cytology Samplesmentioning

confidence: 99%

“…Several ancillary techniques are potentially useful in triaging hrHPV‐positive women to increase the specificity of the test. Other than HPV genotyping that was described above, other molecular markers include those involved in cell cycling (overexpression of p16, HPV viral load, and integration) and those related to epigenetic change (methylation of human and viral genes, and microRNA) 71,75 . These tests can be applied in cervical cytology samples.…”

Section: Molecular Testing Of Hpv In Gynecologic Cytology Samplesmentioning

confidence: 99%

“…These tests can be applied in cervical cytology samples. Although it is promising, most of these molecular tests are still in the research study phase and need clinical validation 71 …”

Section: Molecular Testing Of Hpv In Gynecologic Cytology Samplesmentioning

confidence: 99%

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Molecular diagnostics of infectious disease: Detection and characterization of microbial agents in cytology samples

Caruso

Yang

2022

Diagnostic Cytopathology

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Background Cytology samples are widely used to diagnose various infectious diseases by detection and identification of causative infectious agents, including bacteria, fungi, and viruses. The role of cytopathology in infectious disease has expanded tremendously in the past decades with the advances in molecular techniques. Molecular diagnostic methods, compared to conventional methods, have shown improved patient outcome, reduction in cost, and shortened hospital stay times. The aim of this article is to review molecular testing in cytology samples for diagnosis of infectious diseases. Methods The literature search for molecular testing in common cytology samples for diagnosis of infectious diseases was performed. The findings of the studies were summarized. The common cytology samples included in this article were gynecologic specimens, cerebrospinal fluid, bronchoalveolar lavage, and urine samples. Conclusions There are a number of molecular diagnostic tests that are available to be used in common cytology samples to detect infectious agents. Each test has its own advantages and limitations. It is our hope that upon reading this review article, the readers will have better understanding of molecular diagnostic testing of infectious diseases utilizing commonly sampled cytology specimens in daily practice.

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Section: Other Ancillary Molecular Testsmentioning

confidence: 99%

Section: Molecular Testing Of Hpv In Gynecologic Cytology Samplesmentioning

confidence: 99%

Section: Molecular Testing Of Hpv In Gynecologic Cytology Samplesmentioning

confidence: 99%

“…These tests can be applied in cervical cytology samples. Although it is promising, most of these molecular tests are still in the research study phase and need clinical validation 71 …”

Section: Molecular Testing Of Hpv In Gynecologic Cytology Samplesmentioning

confidence: 99%

See 2 more Smart Citations