Molecular defects of the GNRH receptor gene in Chinese patients with idiopathic hypogonadotropic hypogonadism and the severity of hypogonadism

Mutation profiles and clinical characteristics of Chinese males with isolated hypogonadotropic hypogonadism

“…However, only approximately 40% of IHH patients have mutations in these genes (9), indicating that many genes underlying the pathogenesis of IHH remain to be discovered. In addition, the mutation profiles of IHH patients may vary among different ethnic groups, and few genetic studies have been reported in Chinese patients with IHH (10,11).…”