Molecular design and synthesis of new dithiocarbazate complexes; crystal structure, bioactivities and nano studies

Abstract

New metal complexes are synthesized and characterized by elemental analysis, mass spectrometry, spectroscopic, TGA and X-ray techniques. The compounds were evaluated in an in vitro cytotoxicity. Interaction of the samples with HSA was investigated.

Iron(III) bis‐complexes of Schiff bases of S‐methyldithiocarbazates: Synthesis, structure, spectral and redox properties and cytotoxicity

“…When one mole of iron(III) chloride was reacted with two moles of the ligands, the same bis‐complex of composition [FeL 2 ]Cl (X = Cl ¯ or FeCl 4 ¯ ) was isolated. It may be noted that a complex similar to 3 but with FeCl 4 ¯ counterion has been synthesised already [40d] . All the iron(III) complexes are black crystalline solids, non‐hygroscopic, and air‐stable.…”

“…Closely related to thiosemicarbazones with NNS donor atoms are the Schiff base ligands of S ‐substituted dithiocarbazates (DTCs) with an NNS donor set, the metal complexes of which have been synthesized in recent years and their antitumor, antifungal, and antibacterial activities have been evaluated . They are easily prepared and are widely used as chelating ligands in the synthesis of a large variety of air‐stable metal complexes which possess potential applications in biochemical and pharmacological research .…”

“…Many Schiff base ligands with dithiocarbazate moieties condensed with various heterocyclic aldehydes and ketones act as strong tridentate chelating agents, facilitating coordination of metal ions in different oxidation states through harder nitrogen and soft sulfur donors and confer interesting coordination geometries on metal complexes, a feature that also affects the biological activity of the complexes . Only a few studies based on Schiff bases of dithiocarbazates derived from S ‐alkyl/aryl moieties have been made so far . Also, the iron complexes of dithiocarbazate based ligands are scarce compared to other metal complexes.…”

Homoleptic tin(IV) compounds containing tridentate ONS dithiocarbazate Schiff bases: Synthesis, X-ray crystallography, DFT and cytotoxicity studies

“…There are three related homoleptic tin(IV) compounds that have been structurally characterised in the literature, namely the ethyl thioester and unsubstituted phenoxide residue [50], benzyl thioester, unsubstituted phenoxide residue and methyl bound to the imine-carbon [51] and benzyl thioester with a ferrocenyl substituent adjacent to the alkoxide-oxygen atom [44]. The contrasting and curious feature of the literature structures is that the thiolate- As seen in Fig.…”

Nitroisatin dithiocarbazate: Synthesis, structural characterization, DFT, and docking studies

“…Despite of the chemical similarities of thiosemicarbazones and dithiocarbazates [6], few studies involving isatin dithiocarbazates are available in the literature [7][8][9][10]. Interestingly, isatin derived thiosemicarbazones were investigated as inhibitors of parasitic cysteine proteases identified in trypanosomes (cruzain and rhodesain) and malaria parasites (falcipain-2), presenting a higher activity than their isatin precursors [2].…”