Molecular design of biodegradable polymeric micelles for temperature-responsive drug release

Nakayama, Masamichi; Okano, Teruo; Miyazaki, T.; Kohori, Fukashi; Sakai, Kiyotaka; Yokoyama, M.

doi:10.1016/j.jconrel.2006.07.007

Cited by 350 publications

(217 citation statements)

References 33 publications

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“…Drug release from a thermosensitive polymer micelle upon temperature increase. Reproduced from [37] with permission. Illustration of the "tandem" gelation process.…”

Section: Discussionmentioning

confidence: 99%

“…Recent developments on pNiPAAm-based hydrogels include their use for drug delivery [12,13,37,38], cell encapsulation and delivery [39,40] and cell culture surfaces [41]. Poly(Nisopropylacrylamide) is non-biodegradable and exhibits a sharp phase transition, with an LCST at about 32°C in pure water [37,42].…”

Section: N-isopropylacrylamide-based Systemsmentioning

confidence: 99%

“…Many homo-and copolymers of NiPAAm are not biodegradable [48], a fact that may prove problematic for some biomedical engineering applications. Nakayama and colleagues [37] have prepared thermally responsive, biodegradable polymeric micelles for controlled drug release. A hydrophobic block in the micelles was used to incorporate water-insoluble drugs.…”

Section: N-isopropylacrylamide-based Systemsmentioning

confidence: 99%

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Thermoresponsive hydrogels in biomedical applications

Klouda

Mikos

2008

European Journal of Pharmaceutics and Biopharmaceutics

1,132

696

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Environmentally responsive hydrogels have the ability to turn from solution to gel when a specific stimulus is applied. Thermoresponsive hydrogels utilize temperature change as the trigger that determines their gelling behavior without any additional external factor. These hydrogels have been interesting for biomedical uses as they can swell in situ under physiological conditions and provide the advantage of convenient administration. The scope of this paper is to review the aqueous polymer solutions that exhibit transition to gel upon temperature change. Typically, aqueous solutions of hydrogels used in biomedical applications are liquid at ambient temperature and gel at physiological temperature. The review focuses mainly on hydrogels based on natural polymers, N-isopropylacrylamide polymers, poly(ethylene oxide)-b-poly(propylene oxide)-bpoly(ethylene oxide) polymers as well as poly(ethylene glycol)-biodegradable polyester copolymers.

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“…Drug release from a thermosensitive polymer micelle upon temperature increase. Reproduced from [37] with permission. Illustration of the "tandem" gelation process.…”

Section: Discussionmentioning

confidence: 99%

Section: N-isopropylacrylamide-based Systemsmentioning

confidence: 99%

Section: N-isopropylacrylamide-based Systemsmentioning

confidence: 99%

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Thermoresponsive hydrogels in biomedical applications

Klouda

Mikos

2008

European Journal of Pharmaceutics and Biopharmaceutics

1,132

696

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“…However, when the temperature was kept higher than 40°C, the size remained the same, indicating an LCST of~38°C. The average thickness of the polymer shell on the surface of Cu 7 (Fig. 1f).…”

Section: Synthesis and Characterization Of Nanocompositesmentioning

confidence: 99%

“…Up to now, smart drug delivery platforms triggered by stimuli such as pH [3][4][5][6], temperature [7], magnetic field [8][9][10] and glutathione existing in cytoplasmic matrix [11,12] have been designed, which overcome the current shortcoming of DDSs that release drugs following a predetermined rate after administration, irrespective of the patients' needs [13]. These smart DDSs offer the possibility to remotely and noninvasively control the drug release, which would substantially improve treatment efficacy and reduce side effects [14].…”

Section: Introductionmentioning

confidence: 99%

光热响应的Cu7S4@pNIPAm纳米载体应用于可控的药物/光热治疗

Bai

et al. 2016

Sci. China Mater.

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Drug delivery systems (DDSs) have been getting more and more attention in the field of cancer therapy with the development of nanotechnology. But remote and noninvasive controlled drug release for improving treatment efficacy and reducing side effects faces great challenge. We report a kind of "smart" nanocomposites (NCs) that is sensitive to the surrounding temperature by grafting a layer of thermosensitive polymer, poly(N-isopropylacrylamide) (pNIPAm), on the surface of single Cu7S4 nanoparticle (NP) via atomtransfer radical polymerization (ATRP). These NCs demonstrate a photothermal conversion efficiency of 25.4% under 808-nm near infrared (NIR) light irradiation and a drug loading content of 19.4% (drug/total NCs, w/w) with a lower critical solution temperature (LCST) of~38°C. At normal physiological temperature (37°C), only 10.8% of the loaded doxorubicin (DOX) was released at physiological pH value (pH 7.4) within 10 h. In the presence of 808-nm irradiation, due to the temperature increment as a result of photothermal effects, DOX was rapidly released.

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