Molecular Design of Novel Inhibitor by Targeting IL‐6Rα using Combined Pharmacophore and Experimentally Verified Plant Products with Scaffold‐Hopping Techniques: A Dual Therapeutic Strategy for COVID‐19 and Cancer
Ishani Paul,
Alankar Roy,
Sujay Ray
Abstract:The IL‐6/IL‐6R/gp130 complex serves as a significant indicator of cytokine release syndrome in COVID‐19 and chronic inflammation, increasing the risk of cancer. Therefore, we identified IL‐6Rα as a potential target to block gp130 interaction. Notably, there has been no reception of approval for an orally available drug to serve this purpose, to date. In this study, we targeted IL‐6Rα to inhibit IL‐6Rα/gp130 interaction. The selection of the lead candidate L821 involved the amalgamation of three drug discovery … Show more
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