Molecular detection of Epstein Barr Virus in Women with Breast cancer

Hussein, Areej Atiyah

doi:10.32007/jfacmedbagdad.552643

Cited by 1 publication

(3 citation statements)

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“…Common histopathologic features of breast cancer included invasive ductal carcinoma (IDC), ductal carcinoma-in-situ (DCIS), invasive lobular carcinoma (ILC), ductal, lobular, medullary, and mucinous, with one study reporting a recurrent tumor. 40 A majority of the subjects had breast cancers in stages 1 to 3, with a few in the 4th stage. Breast tissues were preserved as paraffin-embedded tissue or frozen tissue.…”

Section: Resultsmentioning

confidence: 98%

“…Overall, 24 case-control studies with either prospective and/or exploratory studies were included. This study involved research conducted worldwide, namely in Syria 25 , Jordan 26 , Australia 27 – 28 , USA 29 , Iran 30 – 37 , Eritrea 38 , Croatia 39 , Iraq 40 , 41 , Saudi Arabia 4 2 , Portugal, Egypt 41 , 43 , Pakistan 44 , India 4 5 , New Zealand 46 , and Sudan 47 . The study design used in all studies was case control.…”

Section: Resultsmentioning

confidence: 99%

“…They found that EBV was present in 51.85% of breast cancer samples and the expression of the LMP1 gene of EBV was associated with an invasive breast cancer phenotype 25 . Hussein et al report that the types of breast cancers associated with EBV infection varied but invasive breast cancer was the most commonly found 40 . This is supported by Bonnet et al, who were able to find EBV presence in 51% of the tumors by using PCR.…”

Section: Discussionmentioning

confidence: 99%

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Epstein-Barr Viral Infection and the Risk for Breast Cancer: A Systematic Review

Agolli,

Ishak,

Viswanathan

et al. 2023

IJHOSCR

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Background: The prevalence of breast cancer has increased and has currently become one of the most common cancers. Although the majority of the world’s population is infected with Epstein Barr Virus (EBV) during their lives, the severity of symptoms varies and not everyone infected with EBV is diagnosed with cancer. EBV might increase the risk for breast cancer either by activating the HER2/HER3 signaling cascades or by creating a state of prolonged immune stimulation. Materials and Methods: A systematic search of several electronic databases including PubMed, ScienceDirect, Cochrane, EBSCOhost, JSTOR, and Scopus, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was conducted. The primary outcome of this review was to assess the prevalence of people with breast cancer that had a prior EBV infection. Results: For this review, 24 case-control studies were accepted. Our analyses included 1.989 breast cancer cases versus 1.034 control cases. EBV was found to be present in 27.9% of breast cancer cases versus 8.02% found in the normal breast tissue of controls. All affected people were women with a mean age was 48.19 years. The most common type of breast cancer found in EBV-infected tissues was invasive breast cancer. Cases were reported sporadically in a wide geographical distribution, and the prevalence varied from 4.6% - 64.1%. Conclusions: A previous EBV infection might be associated with a higher risk for breast malignancy. The most common type is invasive cancer. It mainly affects women and geographical variances are observed. More studies are necessary to elucidate the role of EBV in the mechanisms of breast cancer. Also, it is crucial to improve the prevention and treatment strategies.

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Section: Resultsmentioning

confidence: 98%