Molecular Detection of<i>Bartonella alsatica</i>in Rabbit Fleas, France

Kernif, Tahar; Parola, Philippe; Ricci, Jean Claude; Raoult, Didier; Rolain, Jean‐Marc

doi:10.3201/eid1612.100696

Cited by 7 publications

(5 citation statements)

References 8 publications

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“…We detected DNA of 3 zoonotic Bartonella species among the 105 rabbit fleas we tested for this study; overall Bartonella prevalence in fleas was 21.9% (23/105), which is comparable to previous prevalence estimates from rabbit fleas in Europe (7,9). This study had several noteworthy findings: B. alsatica DNA was detected in North America, and carnivore-associated Bartonella species occurred in rabbit fleas.…”

Section: Discussionsupporting

confidence: 81%

Detection of Zoonotic Bartonella Pathogens in Rabbit Fleas, Colorado, USA

Sato¹,

Brinkerhoff²,

Hollis³

et al. 2020

Emerg. Infect. Dis.

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Section: Discussionsupporting

confidence: 81%

Detection of Zoonotic Bartonella Pathogens in Rabbit Fleas, Colorado, USA

Sato¹,

Brinkerhoff²,

Hollis³

et al. 2020

Emerg. Infect. Dis.

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“…cunicularis ) can contribute to maintain the transmission cycle of B. alsatica in nature. Two previous reports indicate molecular detection of B. alsatica from S. cuniculi fleas from a European wildcat ( Felis silvestris silvestris ) in Andalusia, Spain [ 19 ] and from wild rabbits from southern France [ 23 ] using PCR and sequencing. In rabbits and fleas studied, we found a DNA sequence homologous to AF312506, with a length of 1273 bases [ 24 ], whereas other authors [ 20 ] described a sequence of 576 bases in length (accession code HM060955) of B. alsatica infecting S. cuniculi, which overlap with AF312506 between bases 399 and 993.…”

Section: Resultsmentioning

confidence: 99%

“…We consider that the prevalence of such variant in rabbits is very low in South Spain (less than 1%) [ 17 ]. A phylogenetic tree considering phylogenetic relations among B. alsatica and other Bartonella species appears in [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

Detection of Bartonella alsatica in European wild rabbit and their fleas (Spilopsyllus cuniculi and Xenopsylla cunicularis) in Spain

Márquez

2015

Parasites & Vectors

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BackgroundBartonella alsatica has been formerly isolated from the blood of wild European rabbit (Oryctolagus cuniculus) and identified as causative agent of human endocarditis and lymphadenitis. Fleas are known biological vectors for Bartonella sp. This report details the specific detection of B. alsatica in three flea species commonly associated with the European wild rabbit in Southern Iberian Peninsula (Odontopsyllus quirosi, Spylopsyllus cuniculi and Xenopsylla cunicularis).MethodsIn the present study we have tested the presence of Bartonella alsatica in 26 European wild rabbit specimens and the fleas that they carrying at the moment of capture. Together to rabbits, captured from different localities of Andalusia (Jaen, Granada and Cordoba provinces), we evaluated three of fleas species that parasitize it usually using molecular techniques [PCR amplification and sequencing of intergenic transcribed spacer (ITS) 16S-23S rRNA].ResultsOver a sample of 26 wild rabbits carrying fleas, positive PCR amplicons for B. alsatica were obtained from 10 rabbits. All positive flea pools for B. alsatica were collected from positive rabbits [33.33% (8/24 pools) of S. cuniculi, 33.33% (5/15 pools) of X. cunicularis and 0% (0/7 pools) of O. quirosi]. In three positive rabbits, a pool of S. cuniculi and two pools of X. cunicularis respectively were negative. After sequencing, only B. alsatica (Genbank accession AF312506) was found in the rabbits sampled as well as in S. cuniculi and X. cunicularis within the respective fleas.ConclusionsThis research confirms the implication of two pulicidae flea species, S. cuniculi and X. cunicularis in the maintenance of infection by B. alsatica in wild rabbit populations throughout the year. The zoonotic character of this bartonellosis emphasizes the need to alert public health authorities and the veterinary community for the risk of infection.

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“…All patients had close contact to rabbits before their symptoms began, implicating rabbits in the transmission cycle of Bartonella species. Spilosyllus cuniculi fleas collected from rabbits in France harbor B. alsatica DNA, are a likely vector between rabbits, and may be a vector that transmits B. alsatica to humans [54].…”

Section: Bartonella In Domestic Animals and The Potential For Tranmentioning

confidence: 99%

Human Bartonellosis: An Underappreciated Public Health Problem?

2019

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Bartonella spp. bacteria can be found around the globe and are the causative agents of multiple human diseases. The most well-known infection is called cat-scratch disease, which causes mild lymphadenopathy and fever. As our knowledge of these bacteria grows, new presentations of the disease have been recognized, with serious manifestations. Not only has more severe disease been associated with these bacteria but also Bartonella species have been discovered in a wide range of mammals, and the pathogens’ DNA can be found in multiple vectors. This review will focus on some common mammalian reservoirs as well as the suspected vectors in relation to the disease transmission and prevalence. Understanding the complex interactions between these bacteria, their vectors, and their reservoirs, as well as the breadth of infection by Bartonella around the world will help to assess the impact of Bartonellosis on public health.

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Molecular Detection ofBartonella alsaticain Rabbit Fleas, France

Cited by 7 publications

References 8 publications

Detection of Zoonotic Bartonella Pathogens in Rabbit Fleas, Colorado, USA

Detection of Zoonotic Bartonella Pathogens in Rabbit Fleas, Colorado, USA

Detection of Bartonella alsatica in European wild rabbit and their fleas (Spilopsyllus cuniculi and Xenopsylla cunicularis) in Spain

Human Bartonellosis: An Underappreciated Public Health Problem?

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