2018
DOI: 10.2147/idr.s177886
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Molecular detection of <em>vanA</em> and <em>vanB</em> genes among vancomycin-resistant enterococci in ICU-hospitalized patients in Ahvaz in southwest of Iran

Abstract: ObjectiveNosocomial infections due to vancomycin-resistant enterococci (VRE) are known as a source of spreading these bacteria. The aim of this prospective study was molecular detection of vanA and vanB genes among VRE isolated from patients admitted to intensive care units (ICUs) in Ahvaz in southwest of Iran.Materials and methodsOverall, 243 non-duplicate rectal swab specimens were collected from ICU-hospitalized patients in teaching hospitals affiliated to Ahvaz Jundishapur University of Medical Sciences, I… Show more

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Cited by 28 publications
(24 citation statements)
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“…[ 16 ], Moosavian et al. [ 19 ] and Gonzalez et al. [ 20 ], Enterococcus species had a high frequency in patients' rectal samples.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…[ 16 ], Moosavian et al. [ 19 ] and Gonzalez et al. [ 20 ], Enterococcus species had a high frequency in patients' rectal samples.…”
Section: Discussionmentioning
confidence: 99%
“…applied samples from the wound, blood, cerebrospinal fluid and pleural fluid [ 1 ]. Moreover, exposure to dissimilar antibiotics, duration of antibiotic therapy, different detection methods and different sample sizes could possibly affect the prevalence rate of Enterococcus species [ 1 , 19 ]. In the current study, 95.1% of patients were under antibiotic therapy and most patients had used different antibiotics such as cephalosporins, aminoglycoside, meropenem and vancomycin for 1–5 days.…”
Section: Discussionmentioning
confidence: 99%
“…6,7 Linezolid resistance in Enterococcus species is related to a mutation in the 23S rRNA gene region as well as the presence of the plasmid-encoded chloramphenicol-florfenicol resistance (cfr) gene. 6,27,28 According to various studies, the rate of linezolid resistance in enterococci is low in Iran (0.7%), Turkey (1%), and Australia (1.3%) 17,23,29 but relatively high in Canada (13.7%). 30 In this study, all VREfm strains were susceptible to daptomycin.…”
Section: Dovepressmentioning
confidence: 99%
“…Moreover, acquired resistance through lateral gene transfer to other available antimicrobial agents, including: beta-lactams, aminoglycosides (high level resistance), macrolides, glycopeptides, and oxazolidinones, makes it more challenging 10. Vancomycin resistant enterococci (VRE) have been reported as a leading cause of outbreaks of hospital-acquired infections and in ICU-hospitalized patients 11,12. Linezolid was the drug of choice for management of infections caused by VRE; however, linezolid resistant enterococci have emerged and are reported 13,14…”
Section: Introductionmentioning
confidence: 99%