Molecular determinants of immunogenic cell death elicited by radiation therapy

Galassi, Claudia; Klapp, Vanessa; Yamazaki, Takahiro; Galluzzi, Lorenzo

doi:10.1111/imr.13271

Cited by 13 publications

(2 citation statements)

References 226 publications

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“…RT has been shown to elicit ICD, a typical manifestation of which is abscopal effect ( Galassi et al, 2023 ; Hannon et al, 2023 ) ( Table 1 ). Abscopal effect refers to an immune-related phenomenon in metastatic tumors, irradiating the orthotopic tumor leads to the inhibitory effect on non-orthotopic tumor cells.…”

Section: Icd Inducers and Molecular Mechanismmentioning

confidence: 99%

Clinical application of immunogenic cell death inducers in cancer immunotherapy: turning cold tumors hot

Han,

Tian,

Zhai

et al. 2024

Front. Cell Dev. Biol.

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Immunotherapy has emerged as a promising cancer treatment option in recent years. In immune “hot” tumors, characterized by abundant immune cell infiltration, immunotherapy can improve patients’ prognosis by activating the function of immune cells. By contrast, immune “cold” tumors are often less sensitive to immunotherapy owing to low immunogenicity of tumor cells, an immune inhibitory tumor microenvironment, and a series of immune-escape mechanisms. Immunogenic cell death (ICD) is a promising cellular process to facilitate the transformation of immune “cold” tumors to immune “hot” tumors by eliciting innate and adaptive immune responses through the release of (or exposure to) damage-related molecular patterns. Accumulating evidence suggests that various traditional therapies can induce ICD, including chemotherapy, targeted therapy, radiotherapy, and photodynamic therapy. In this review, we summarize the biological mechanisms and hallmarks of ICD and introduce some newly discovered and technologically innovative inducers that activate the immune system at the molecular level. Furthermore, we also discuss the clinical applications of combing ICD inducers with cancer immunotherapy. This review will provide valuable insights into the future development of ICD-related combination therapeutics and potential management for “cold” tumors.

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Section: Icd Inducers and Molecular Mechanismmentioning

confidence: 99%

Clinical application of immunogenic cell death inducers in cancer immunotherapy: turning cold tumors hot

Han,

Tian,

Zhai

et al. 2024

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

“…Such antigens can be microbial (for instance in the context of infection by viruses or intracellular bacteria), tumor-associated, or autoantigens. Immunogenic cell death is not only induced by drugs but can also occur in the context of radiation therapy, 12 photodynamic, and photothermal therapy, 13 as well upon infection by microbes including oncolytic viruses. 14 Logically, attempts are underway to create novel galenic formulation including nanoparticle-based drug delivery systems to administer drugs that induce immunogenic cell death in tumors, yet do not mediate any systemic effects.…”

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confidence: 99%