Molecular Determinants of Magnesium Homeostasis

Alexander, R. Todd; Hoenderop, Joost G. J.; Bindels, René J. M.

doi:10.1681/asn.2008010098

Cited by 139 publications

(90 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…18 Mg 2ϩ may enter the cell down an electrochemical activity gradient through channels such as TrpM6 and TrpM7. 21 It is less clear how the ion is removed from the cells to maintain the gradient. For Mg 2ϩ to have an influence on ROMK channel activity, the effective affinity, determined by both voltage-independent and voltage-dependent processes, would need to be in the millimolar range.…”

Section: Discussionmentioning

confidence: 99%

Magnesium Modulates ROMK Channel–Mediated Potassium Secretion

Yang

Frindt

Palmer

2010

Journal of the American Society of Nephrology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Magnesium Modulates ROMK Channel–Mediated Potassium Secretion

Yang

Frindt

Palmer

2010

Journal of the American Society of Nephrology

View full text Add to dashboard Cite

show abstract

“…In mice kidneys, claudin-16 and claudin-19 are expressed in the medullary and cortical thick ascending limb of the loop of Henle (5), where they are colocalized to tight junction proteins and form a cation-selective complex (6). Although their role remains poorly understood (7,8), they probably modulate the passive paracellular magnesium (Mg 2ϩ ) and calcium (Ca 2ϩ ) transport in these tubular segments, which is driven by an electrical gradient resulting from potassium (K ϩ ) exit across apical membranes through the renal outer-medullary K ϩ channel and chloride (Cl Ϫ ) and sodium (Na ϩ ) exit across basal membranes through the Cl Ϫ channel and Na ϩ -K ϩ -ATPase, respectively (9).…”

Section: Introductionmentioning

confidence: 99%

Renal, Ocular, and Neuromuscular Involvements in Patients with CLDN19 Mutations

Faguer¹,

Chauveau²,

Pascal³

et al. 2011

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

SummaryBackground and objectives The objective of this study was to describe the renal and extrarenal findings in patients with recessively inherited familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) associated with CLDN19 mutations.Design, setting, participants, & measurements Medical records of three patients from two French unrelated families with CLDN19 mutations were retrospectively examined.Results Direct sequencing of CLDN19 identified a known variant (p.Gly20Asp) in all patients and a new missense mutation (p.Val44Met) in one (compound heterozygous). The patients' renal phenotype closely mimicked CLDN16-related nephropathy: low serum Mg 2ϩ (Ͻ0.65 mmol/L) despite oral supplementation, hypercalciuria partly thiazide-sensitive, and progressive renal decline with ESRD reached at age 16 and 22 years in two individuals. Primary characteristics (failure to thrive, recurrent urinary tract infections, or abdominal pain), age at onset (0.8 to 16 years), and rate of renal decline were highly heterogeneous. Ocular involvement was identified in all patients, although two patients did not have visual loss. Additionally, exercise intolerance with pain, weakness, and electromyographical alterations mimicking a Ca 2ϩ /K ϩ channelopathy (pattern V) were observed in two of three individuals. These features persisted despite the normalization of serum K ϩ and Mg 2ϩ after renal transplantation.Conclusions Ocular manifestations, even subtle, and exercise intolerance mimicking mild to moderate periodic paralysis are two symptoms that need to be searched for in patients with FHHNC and may indicate CLDN19 mutations.

show abstract

“…Thus, an increased rate of proliferation is associated with TRPM-6 and TRPM-7 complex formation, in which magnesium enters the cell to fulfill magnesium-dependent enzymes for energy production and energy consumption, protein synthesis, fatty acids, phospholipids etc. By the way, magnesium ions optimize conditions for a normal blood flow in organs and tissues [1,3].…”

Section: оригинальные исследованияmentioning

confidence: 99%

Interrelation of endothelial nitric oxides synthase activity in tissues of the stomach and magnesium balance in the period of erosive-ulcerative acid-induced lesion development in rats with different resistance to stress

Nikolaevna¹,

Nikolaevna²

2017

Medical news of the North Caucasus

View full text Add to dashboard Cite

Волгоградский государственный медицинский университет, Российская ФедерацияAcetate stomach ulcer was experimentally modeled in stress resistant and stress nonresistant rats for immunohistochemical identifying a specific number and expression intensity of eNOS-positive cells and determination of the magnesium level in biological media. The content of intra-erythrocyte magnesium in reaction with titanium yellow was reduced in rats with different resistance to stress in low eNOS activity in the gastric mucosa, in the muscular layer in stress nonresistant animals and almost complete absence of antigen-positive cells in the submucosa. A positive correlation was found between the level of intra-erythrocyte magnesium and the specific number of eNOS-positive cells in the gastric mucosa in both groups of animals and also between expression intensity in the submucosa of stress nonresistant rats. A relationship was established between the magnesium content, specific number and expression intensity of eNOS in stress nonresistant rats in the stomach submucosa.

show abstract

Molecular Determinants of Magnesium Homeostasis

Cited by 139 publications

References 88 publications

Magnesium Modulates ROMK Channel–Mediated Potassium Secretion

Magnesium Modulates ROMK Channel–Mediated Potassium Secretion

Renal, Ocular, and Neuromuscular Involvements in Patients with CLDN19 Mutations

Interrelation of endothelial nitric oxides synthase activity in tissues of the stomach and magnesium balance in the period of erosive-ulcerative acid-induced lesion development in rats with different resistance to stress

Contact Info

Product

Resources

About