Molecular diagnostics in haematopathology

Byers, Richard; Tholouli, Eleni

doi:10.1016/j.mpdhp.2008.03.003

Cited by 5 publications

(2 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, several non-neoplastic lymphoid disorders (i.e. infectious mononucleosis, monoclonal lymphoid disease of uncertain significance and monoclonal gammopathy of uncertain significance) have been associated to monoclonal IgH and/or TCR rearrangements (5)(6).…”

Section: Pcr Clonality Testsmentioning

confidence: 99%

“…In recent years, the development of relatively cheap molecular assays, such as polymerase chain reaction (PCR), has represented a turning point in the field of diagnostic hematopathology: many genetic studies, previously performed only in research laboratories, have in fact become available also for routine diagnostic practice, thus improving the reliability of immunohistological diagnoses (6).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The role of molecular biology in the diagnosis of lymphoid neoplasms

et al. 2014

View full text Add to dashboard Cite

In recent years, DNA-arrays, gene expression profiling and next-generation sequencing have elucidated the high complexity of genomic alterations occurring in lymphoid malignancies. These studies have also contributed to the identification of new diagnostic and prognostic biomarkers, which may represent possible targets for new therapeutic approaches. Such recent advances have significantly expanded the application of molecular tests to routine diagnostic hematopathology. It is thus conceivable that next-generation assays will soon flank traditional clonality tests and chromosomal translocation assays in the diagnostic work-up of difficult cases. This review is focused on the application of molecular biology techniques in the study of lymphoid tumors. Both conventional and next-generation tests will be addressed, with particular attention to their application to clinical practice.

show abstract

Section: Pcr Clonality Testsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%