2020
DOI: 10.3897/rrpharmacology.6.53332
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Molecular docking, ADMET study and in vivo pharmacological research of N-(3,4-dimetoxyphenyl)-2-{[2-methyl-6-(pyridine-2-yl)-pyrimidin-4-yl]thio}acetamide as a promising anticonvulsant

Abstract: Introduction: The search for new anticonvulsants for epilepsy treatment with higher efficacy and better tolerability remains important. The aim of the present research was an in silico and in vivo pharmacological study of N-(3,4-dimethoxyphenyl)-2-((2-methyl-6-(pyridin-2-yl)pyrimidin-4-yl)thio)acetamide (Epirimil) as a promising anticonvulsant. Materials and methods: A 1H and 13C NMR spectroscopy, LS/MS, and an elemental analysis were used to determine Epirimil structure. An ADMET analysis, as well a… Show more

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Cited by 3 publications
(1 citation statement)
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“…The picture of poisoning and the dynamics of the development of intoxication symptoms depended on the administered dosage. Subcutaneous administration of MONISEN ® forte to white nonlinear mice in the dose of 1800-2700 mg/kg led to a decrease in the dynamics of weight gain [18,19]. At the same time, when the drug was administered in the dose of 1800-2100 mg/kg of body weight, although it led to a decrease in the dynamics of weight gain, nevertheless, on the 14th day after administration of the drug, these animals showed a positive average daily weight gain for 14 days and amounted to 108.…”
Section: Resultsmentioning
confidence: 96%
“…The picture of poisoning and the dynamics of the development of intoxication symptoms depended on the administered dosage. Subcutaneous administration of MONISEN ® forte to white nonlinear mice in the dose of 1800-2700 mg/kg led to a decrease in the dynamics of weight gain [18,19]. At the same time, when the drug was administered in the dose of 1800-2100 mg/kg of body weight, although it led to a decrease in the dynamics of weight gain, nevertheless, on the 14th day after administration of the drug, these animals showed a positive average daily weight gain for 14 days and amounted to 108.…”
Section: Resultsmentioning
confidence: 96%