Molecular docking studies, anti-Alzheimer’s disease, antidiabetic, and anti-acute myeloid leukemia potentials of narcissoside

Liu, Tingting; Cao, Lixia; Zhang, Tingting; Fu, Huan

doi:10.1080/13813455.2020.1828483

Cited by 11 publications

(9 citation statements)

References 97 publications

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“…On one hand, the good antioxidant effect observed for the rare flavonoid narcissoide ( iso ‐rhamnetin‐3‐ O ‐rutinoside, 9 ) is quite remarkable, with SC 50 values of 82.82 μM and 12.43 μM in DPPH and ABTS assays, respectively. In contrast to our study, the literature reported a moderate antioxidant capacity for the same product [41] . In addition to the antioxidant and antiradical activities, notoriously common to many polyphenolic compounds, others more interesting biological properties have been described.…”

Section: Resultscontrasting

confidence: 99%

A Rare Dirhamnosyl Flavonoid and Other Radical‐Scavenging Metabolites from Cynophalla mollis (Kunth) J. Presl and Colicodendron scabridum (Kunt) Seem. (Capparaceae) of Ecuador

Morocho

Valarezo

Tapia

et al. 2021

Chemistry & Biodiversity

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The phytochemistry of Cynophalla mollis (Kunth) J. Presl and Colicodendron scabridum (Kunth), both belonging to the family Capparaceae, were investigated in this study for the first time. Lupeol, betulin, lutein, stachydrine and quercetin‐3,4’‐di‐O‐rhamnoside were isolated from C. mollis, whereas C. scabridum afforded lupeol, lutein, stachydrine, β‐sitosterol, stigmasterol, betonicine and narcissoside. All these compounds were purified by preparative liquid chromatography, in both open column and instrumental (MPLC) separation systems. Preparative TLC was also applied. They were all identified by 1H‐ and 13C‐NMR experiments. The complete structure of the very rare flavonoid quercetin‐3,4’‐di‐O‐rhamnoside was fully elucidated through DEPT‐135, COSY, HMQC and HMBC experiments, together with UV/VIS and FT‐IR spectrophotometry. Complete NMR data for quercetin‐3,4’‐di‐O‐rhamnoside in deuterated methanol were presented here for the first time. All the extracts did not exert antioxidant activity at the maximum tested dose of 1 mg/mL. Three out of the nine isolated compounds exerted a good spectrum of antioxidant capacity, being narcissoside the most active against ABTS radicals, with SC50=12.43 μM. It was followed by lutein and quercetin‐3,4’‐di‐O‐rhamnoside, with 40.92 μM and 46.10 μM, respectively.

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Section: Resultscontrasting

confidence: 99%

A Rare Dirhamnosyl Flavonoid and Other Radical‐Scavenging Metabolites from Cynophalla mollis (Kunth) J. Presl and Colicodendron scabridum (Kunt) Seem. (Capparaceae) of Ecuador

Morocho

Valarezo

Tapia

et al. 2021

Chemistry & Biodiversity

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“…Diabetes and inflammation are known risk factors for inducing PD, and the NSC has the potency to ease these factors [ 101 ]. It is worth mentioning that recent studies have shown that NSCs can fight against COVID-19 [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective Capability of Narcissoside in 6-OHDA-Exposed Parkinson’s Disease Models through Enhancing the MiR200a/Nrf-2/GSH Axis and Mediating MAPK/Akt Associated Signaling Pathway

Tsai

Liu

et al. 2022

Antioxidants

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We assessed the antioxidant potential of narcissoside from Sambucus nigra flowers (elderflowers) in Parkinson’s disease models in vitro and in vivo. The results showed that narcissoside lessened the 6-hydroxydopamine (6-OHDA)-induced increase in reactive oxygen species (ROS) and apoptosis in SH-SY5Y cells. In the 6-OHDA-exposed Caenorhabditis elegans model, narcissoside reduced degeneration of dopaminergic neurons and ROS generation, and also improved dopamine-related food-sensitive behavior and shortened lifespan. Moreover, NCS increased total glutathione (GSH) by increasing the expression of the catalytic subunit and modifier subunit of γ-glutamylcysteine ligase in cells and nematodes. Treatment with a GSH inhibitor partially abolished the anti-apoptotic ability of narcissoside. Furthermore, narcissoside diminished the 6-OHDA-induced phosphorylation of JNK and p38, while rising activities of ERK and Akt in resisting apoptosis. The antioxidant response element (ARE)-luciferase reporter activity analysis and electromobility gel shift assay showed that narcissoside promotes the transcriptional activity mediated by Nrf2. Finally, we found that narcissoside augmented the expression of miR200a, a translational inhibitor of the Nrf2 repressor protein Keap1. Downregulation of Nrf2 and miR200a by RNAi and anti-miR200a, respectively, reversed the neuroprotective ability of narcissoside. In summary, narcissoside can enhance the miR200a/Nrf2/GSH antioxidant pathway, alleviate 6-OHDA-induced apoptosis, and has the neuroprotective potential.

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“…Isoquercitrin has high bioavailability and exerts several chemoprotective effects, both in vitro and in vivo, against oxidative stress, cancer, cardiovascular disorders, diabetes, and allergic reactions [ 32 ]. Narcissoside has antioxidant, anticholinergic, antidiabetic, anti-acute myeloid leukemia, and antiviral effects [ 33 , 34 ]. Kaempferol-3-O-rutinoside has anti-inflammatory, anti-saccharification, and hypotensive effects [ 16 , 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Citric Acid Changes the Fingerprint of Flavonoids and Promotes Their Accumulation in Phellinus igniarius (L.) Quél

Dong

Chen

et al. 2022

Life

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Phellinus igniarius is a valuable medicinal fungus. P. igniarius is rich in a variety of chemical compounds with medicinal value, among which are flavonoids. Therefore, increasing the content of flavonoids in P. igniarius is beneficial for its potential use in medicinal applications. This study demonstrated that exogenous treatment with citric acid (CA) could significantly increase flavonoid accumulation in P. igniarius. Additionally, we found that CA induced the biosynthesis of flavonoids in a concentration- and time-dependent manner. The flavonoid content could be increased up to 60.96 mg/g when using the treatment with 2.77 mM citric acid for 69.74 h, which was determined by using the response surface method. The changes in the fingerprint profiles of P. igniarius flavonoids with the treatment of CA as an exogenous inducer were also analyzed. In this study, the effect of citric acid as the exogenous inducer on the flavonoid content of P. igniarius was studied, and the processing conditions were optimized through the surface response curve. This approach provides novel insights and a theoretical basis for the production of high-quality P. igniarius.

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Molecular docking studies, anti-Alzheimer’s disease, antidiabetic, and anti-acute myeloid leukemia potentials of narcissoside

Cited by 11 publications

References 97 publications

A Rare Dirhamnosyl Flavonoid and Other Radical‐Scavenging Metabolites from Cynophalla mollis (Kunth) J. Presl and Colicodendron scabridum (Kunt) Seem. (Capparaceae) of Ecuador

A Rare Dirhamnosyl Flavonoid and Other Radical‐Scavenging Metabolites from Cynophalla mollis (Kunth) J. Presl and Colicodendron scabridum (Kunt) Seem. (Capparaceae) of Ecuador

Neuroprotective Capability of Narcissoside in 6-OHDA-Exposed Parkinson’s Disease Models through Enhancing the MiR200a/Nrf-2/GSH Axis and Mediating MAPK/Akt Associated Signaling Pathway

Citric Acid Changes the Fingerprint of Flavonoids and Promotes Their Accumulation in Phellinus igniarius (L.) Quél

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