Molecular domestication — more than a sporadic episode in evolution

Miller, Wolfgang J.; McDonald, John F.; Nouaud, Danielle; Anxolabéhère, Dominique

doi:10.1007/978-94-011-4156-7_22

Cited by 60 publications

(67 citation statements)

References 67 publications

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“…Although transposable elements have classically been viewed as selfish parasites, there is an increasing perspective that it may be more accurate to consider the entire coevolutionary spectrum that different elements may occupy: from parasite to mutualist providing essential host functions (Miller et al 1999;Kidwell and Lisch 2000;Gregory 2005). Our identification of model systems such as the megabats, and dissection of the components of their genomes, should allow us to clarify the placement of L1s within this spectrum, and as a result increase our understanding of how they affect their mammalian hosts.…”

Section: Discussionmentioning

confidence: 99%

Loss of LINE-1 Activity in the Megabats

et al. 2008

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LINE-1 (L1) retrotransposons are the most abundant type of mammalian retroelement. They have profound effects on genome plasticity and have been proposed to fulfill essential host functions, yet it remains unclear where they lie on the spectrum from parasitism to mutualism. Their ubiquity makes it difficult to determine the extent of their effects on genome evolution and gene expression because of the relative dearth of animal models lacking L1 activity. We have isolated L1 sequences from 11 megabat species by a method that enriches for recently inserted L1s and have done a bioinformatic examination of L1 sequences from a 12th species whose genome was recently shotgun sequenced. An L1 extinction event appears to have occurred at least 24 million years ago (MYA) in an ancestor of the megabats. The ancestor was unusual in having maintained two highly divergent long-term L1 lineages with different levels of activity, which appear, on an evolutionary scale, to have simultaneously lost that activity. These megabat species can serve as new animal models to ask what effect loss of L1 activity has on mammalian genome evolution and gene expression.

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Section: Discussionmentioning

confidence: 99%

Loss of LINE-1 Activity in the Megabats

et al. 2008

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“…It has been argued (Miller et al 1999) that these examples of domestication represent more than just isolated examples of an infrequent process. Rather, the adaptive integration of a short piece of autonomous DNA into a complex regulatory network that occurs in molecular domestication might be considered to represent an evolutionary process that has been common in the evolution of increasingly complex forms of life.…”

Section: Host Recruitment Of Enzymatic Functionsmentioning

confidence: 99%

Perspective: Transposable Elements, Parasitic Dna, and Genome Evolution

2001

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Abstract. The nature of the role played by mobile elements in host genome evolution is reassessed considering numerous recent developments in many areas of biology. It is argued that easy popular appellations such as ''selfish DNA'' and ''junk DNA'' may be either inaccurate or misleading and that a more enlightened view of the transposable element-host relationship encompasses a continuum from extreme parasitism to mutualism. Transposable elements are potent, broad spectrum, endogenous mutators that are subject to the influence of chance as well as selection at several levels of biological organization. Of particular interest are transposable element traits that early evolve neutrally at the host level but at a later stage of evolution are co-opted for new host functions.

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“…These mechanisms represent fundamentally different modes of mobilization, use different molecular processes, and have different implications from the perspective of evolutionary changes in genome size. Recent years have witnessed renewed interest in the potential ability of transposable elements to impact the evolution of genes and genomes in plant and animal systems (McDonald, 1995;SanMiguel et al, 1996;Kidwell and Lisch, 1997;Miller et al, 1999;Bennetzen, 2000;van de Lagemaat et al, 2003;DeBarry et al, 2006;Hawkins et al, 2006;Ungerer et al, 2006;Feschotte, 2008).…”

Section: Introductionmentioning

confidence: 99%

Different scales of Ty1/copia-like retrotransposon proliferation in the genomes of three diploid hybrid sunflower species

et al. 2010

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Activation of transposable elements in species' genomes represents an important mechanism of new mutation and of potential rapid change in genome size. Thus, it is increasingly recognized that transposable elements likely have played a significant role in shaping species' evolution. In an earlier report, we showed that the genomes of three sunflower species of ancient hybrid origin have experienced large-scale proliferation events of sequences within the Ty3/ gypsy-like superfamily of long terminal repeat (LTR) retrotransposons. In this report, we investigate whether another superfamily of LTR retrotransposon (Ty1/copia-like elements) have experienced similar derepression and proliferation events in the genomes of these sunflower hybrid taxa. We show that Ty1/copia-like elements also have undergone copy number increases following or associated with the origins of these species, although the scale of proliferation is less than that for Ty3/gypsy-like elements. Surveys of sequence heterogeneity of Ty1/copia-like elements in the genomes of the three hybrid and two parental species' genomes reveal that a single sub-lineage of these elements exhibits characteristics of recent amplification, and likely served as the proliferative source lineage. These findings indicate that the genomic and/or environmental conditions associated with the origins of these sunflower hybrid taxa were conducive to derepression of at least two major groups of transposable elements.

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Molecular domestication — more than a sporadic episode in evolution

Cited by 60 publications

References 67 publications

Loss of LINE-1 Activity in the Megabats

Loss of LINE-1 Activity in the Megabats

Perspective: Transposable Elements, Parasitic Dna, and Genome Evolution

Different scales of Ty1/copia-like retrotransposon proliferation in the genomes of three diploid hybrid sunflower species

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