With considering the scattering effect of grain boundary and the grain orientation, the molecular dynamics is used for the first time to comparatively investigate microjetting generated by monocrystalline tin surface and polycrystalline tin surface under plane impact loading in this work. The research results show that when the impact velocity is low, the scattering effect of grain boundary and different grain orientations in a polycrystalline tin will cause the sample to melt inhomogeneously, leading the shock wave front to attenuate, meanwhile, the inhomogeneous melting can result in jet deviating. Comparing with monocrystalline tin, the jet head velocity, jet velocity coefficient, and jet mass coefficient of polycrystalline tin at low impact velocity are all low. Moreover, as the impact velocity increases, this influence decreases and the microjetting results of polycrystalline tin and monocrystalline tin tend to be consistent with each other.