Molecular effect of fenofibrate on PBMC gene transcription related to lipid metabolism in patients with metabolic syndrome

Abstract

Treatment with fenofibrate reduced fasting and postprandial serum triglyceride levels, possibly through a mechanism related with an increase in the expression of RXRα and PPARα, by activating the pathways involved in the uptake and degradation of triglycerides and increasing the synthesis of apolipoprotein. These results suggest that PBMC may be useful for the easy study of fenofibrate actions.

Phenolic Compounds of Propolis Alleviate Lipid Metabolism Disorder

“…Given to these health issues, many researchers have been alarmed that obesity can be driven by a high and growing prevalence of metabolic syndrome [4,5]. Although the concept of metabolic syndrome may not reach a universal agreement yet [6,7], there is an inextricable connection between metabolic syndrome and lipid metabolism disorder [8,9]. To alleviate lipid metabolism disorder, many drugs have been proved to be an effective approach.…”