Molecular elucidation of pancreatic elastase inhibition by baicalein

The process of choosing the most proper technique for studying the molecular interactions is based on critical factors such as instrumentation complexity, automation, experimental procedures, analysis time, consumables, and costvalue. This review has tracked the use of affinity capillary electrophoresis (ACE) and microscale thermophoresis (MST) techniques in the evaluation of molecular binding among different molecules during the 5 years 2016-2021. ACE has proved to be an attractive technique for biomolecular characterization with high resolution efficiency where small variations in several controlling factors can much improve such efficiency compared to other analytical techniques. Meanwhile, MST has proved its higher sensitivity for smaller amounts of complex non-purified biosamples without affecting its robustness while providing high through output. However, the main motivation to review both techniques in the proposed review was their capability to carry out all experiments without the

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Studying molecular interactions via capillary electrophoresis and microscale thermophoresis: A review

Asmari

Michalcová

Ibrahim

et al. 2023

Electrophoresis

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Thalidomide derivatives as nanomolar human neutrophil elastase inhibitors: Rational design, synthesis, antiproliferative activity and mechanism of action

Donarska

Sławińska-Brych

Mizerska-Kowalska

et al. 2023

Bioorganic Chemistry

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Inhibition mechanism of baicalein against alcohol dehydrogenase in vitro via biological techniques, spectroscopy and computer simulation

Yang

Lei²,

Zhou³

et al. 2022

Journal of Molecular Liquids

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Molecular elucidation of pancreatic elastase inhibition by baicalein

Abstract: Plot. Absorbance values (OD 405nm ) were used as an estimate for velocities of the reaction at different substrate concentrations. The Vmax and Km values were 0.461 and 1.02 mM respectively.

Cited by 4 publications

References 38 publications

Studying molecular interactions via capillary electrophoresis and microscale thermophoresis: A review

Studying molecular interactions via capillary electrophoresis and microscale thermophoresis: A review

Thalidomide derivatives as nanomolar human neutrophil elastase inhibitors: Rational design, synthesis, antiproliferative activity and mechanism of action

Inhibition mechanism of baicalein against alcohol dehydrogenase in vitro via biological techniques, spectroscopy and computer simulation

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