Molecular encapsulation study of indole-3-methanol in cyclodextrins: Effect on antimicrobial activity and cytotoxicity

Synthesis and Characterization of an Inclusion Complex of dl-Aminoglutethimide with β-Cyclodextrin and Its Innovative Application in a Biological System: Computational and Experimental Investigations

“…This behavior of the inclusion complex might be due to the controlled release of the drug from the cavity of β-CD. 14 …”

“…The most widely accepted host for complex formation is β-CD due to its suitable cavity diameter and low production cost. , β-Cyclodextrin consists of seven α- d -glucopyranose units joined by α-1,4-linkages . Cyclodextrins are able to modify the pharmacological properties of the encapsulated active substances such as solubility, bioavailability, chemical stability, dispersibility, and toxicity; thus, by the preparation of inclusion complexes with cyclodextrin molecules it can be possible to enhance or improve such properties of the active compounds. − …”

Thermodynamic Studies of Interactions between Sertraline Hydrochloride and Randomly Methylated β-Cyclodextrin Molecules Supported by Circular Dichroism Spectroscopy and Molecular Docking Results

“…Cyclodextrins are water-soluble cyclic oligo-saccharides with a truncated cone-structure possessed a hydrophobic cavity and hydrophilic outer surface border [1]. Recently, the guesthost cyclodextrin complex formations were examined for many and different ligands like for example: remdesivir [2], water-soluble betulin derivatives [3], thiabendazole [4], ethinyloestradiol [5], bis(1,10-phenanthroline) silver (I) salicylate [6], oncocalyxone A [7], or β-cyclodextrinenhanced Eu 3+ luminescence aggregates with bright red fluorescence of Eu 3+ convenient for environmental detection system [8] and many others [9][10][11][12]. Reactions involving cyclodextrins are still important to the separation [13,14] and food industry [15][16][17] or other kinds of industries [18,19], but mostly to drug delivery systems for various applications in the field of medical biomaterials for example in the technology of polymers to get artificial abdominal wall prosthesis textile with improved biological and antibiotic delivery properties [20].…”

“…The aim of presented work was to obtain information about interactions of sertraline hydrochloride (SRT) (Figure 1a) with randomly methylated β-cyclodextrin (RMβCD) (Figure 1b) in water solutions at 298.15 K under atmospheric pressure. The binding process of guest molecule with cyclodextrin was examined with the use of an isothermal titration calorimetry (ITC) [43][44][45] and molecular docking studies (MD) [10,43,45]. The outcome was compared with the set of data for other complexes of SRT with non-ionic β-cyclodextrin derivatives (Figure 1b) received from the literature [31,41,42].…”

Exploring the Inclusion Complex of a Drug (Umbelliferone) with α-Cyclodextrin Optimized by Molecular Docking and Increasing Bioavailability with Minimizing the Doses in Human Body

“…Cyclodextrins are well-known cyclic oligosaccharides consisting of six, seven, or eight α-(1 → 4)- d -glucoside moieties, giving rise to α-, β-, and γ-CDs, respectively. − Owing to their nontoxic nature and complexation ability, CDs are generally regarded as safe and have received widespread attention for application in food, agriculture, cosmetics, and pharmaceutical industries. − Recently, various works have been carried out with different organic UV-absorbing agents with cyclodextrins, for example, Mori et al shown that octylmethoxy cinnamate and avobenzone have been formulated with different cyclodextrins into cosmetic sunscreens. These kinds of chemical modifications through supramolecular complexation possibly will enhance the substance concentration in the upper skin layers by reducing its percutaneous penetration.…”