Molecular engineering of metal-based photosensitizers with narrow band gap for efficient photodynamic therapy

Shi, Pengmin; Gong, Wenqi; Zhao, Jian; Jiao, Yubo; Sun, Yanyan; Fang, Lei; Gou, Shaohua

doi:10.1039/d4cc02347a

Chem. Commun.

2024

DOI: 10.1039/d4cc02347a

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Molecular engineering of metal-based photosensitizers with narrow band gap for efficient photodynamic therapy

Pengmin Shi,

Wenqi Gong,

Jian Zhao

et al.

Abstract: Three iridium(iii) complexes were designed with the purpose of investigating the photo-physicochemical behaviors of iridium(iii) complexes with narrow band gap for photodynamic therapy.

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Leveraging the Photofunctions of Transition Metal Complexes for the Design of Innovative Phototherapeutics

Lee,

2024

Small Methods

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Despite the advent of various medical interventions for cancer treatment, the disease continues to pose a formidable global health challenge, necessitating the development of new therapeutic approaches for more effective treatment outcomes. Photodynamic therapy (PDT), which utilizes light to activate a photosensitizer to produce cytotoxic reactive oxygen species (ROS) for eradicating cancer cells, has emerged as a promising approach for cancer treatment due to its high spatiotemporal precision and minimal invasiveness. However, the widespread clinical use of PDT faces several challenges, including the inefficient production of ROS in the hypoxic tumor microenvironment, the limited penetration depth of light in biological tissues, and the inadequate accumulation of photosensitizers at the tumor site. Over the past decade, there has been increasing interest in the utilization of photofunctional transition metal complexes as photosensitizers for PDT applications due to their intriguing photophysical and photochemical properties. This review provides an overview of the current design strategies used in the development of transition metal complexes as innovative phototherapeutics, aiming to address the limitations associated with PDT and achieve more effective treatment outcomes. The current challenges and future perspectives on the clinical translation of transition metal complexes are also discussed.

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Leveraging the Photofunctions of Transition Metal Complexes for the Design of Innovative Phototherapeutics

Lee,

2024

Small Methods

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Molecular engineering of metal-based photosensitizers with narrow band gap for efficient photodynamic therapy

Abstract: Three iridium(iii) complexes were designed with the purpose of investigating the photo-physicochemical behaviors of iridium(iii) complexes with narrow band gap for photodynamic therapy.

Cited by 1 publication

References 36 publications

Leveraging the Photofunctions of Transition Metal Complexes for the Design of Innovative Phototherapeutics

Leveraging the Photofunctions of Transition Metal Complexes for the Design of Innovative Phototherapeutics

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